6QDU

Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC

Summary for 6QDU

Entry DOI	10.2210/pdb6qdu/pdb
Descriptor	14-3-3 protein sigma, FC-NCPC, PHOSPHOTHREONINE, ... (6 entities in total)
Functional Keywords	neuron regeneration, ppi, phosphorylation, chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	27487.28
Authors	Andrei, S.A.,Kaplan, A.,Fournier, A.E.,Ottman, C. (deposition date: 2019-01-02, release date: 2020-01-29, Last modification date: 2024-01-24)
Primary citation	Kaplan, A.,Andrei, S.A.,van Regteren Altena, A.,Simas, T.,Banerjee, S.L.,Kato, N.,Bisson, N.,Higuchi, Y.,Ottmann, C.,Fournier, A.E. Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27:657-667.e6, 2020 Cited by PubMed: 32220335 DOI: 10.1016/j.chembiol.2020.02.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.632 Å)

Structure validation