6QHL
14-3-3 sigma with RelA/p65 binding site pS45
Summary for 6QHL
Entry DOI | 10.2210/pdb6qhl/pdb |
Descriptor | 14-3-3 protein sigma, Transcription factor p65, GLYCEROL, ... (4 entities in total) |
Functional Keywords | 14-3-3, p65, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 29878.21 |
Authors | Wolter, M.,Ottmann, C. (deposition date: 2019-01-16, release date: 2020-05-13, Last modification date: 2020-12-30) |
Primary citation | Wolter, M.,de Vink, P.,Neves, J.F.,Srdanovic, S.,Higuchi, Y.,Kato, N.,Wilson, A.,Landrieu, I.,Brunsveld, L.,Ottmann, C. Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142:11772-11783, 2020 Cited by PubMed: 32501683DOI: 10.1021/jacs.0c02151 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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