6NV2
14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005
Summary for 6NV2
Entry DOI | 10.2210/pdb6nv2/pdb |
Related | 6QHM |
Descriptor | 14-3-3 protein sigma, Transcription factor p65, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | fusicoccanes, natural products, p65, 1433, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28503.43 |
Authors | Wolter, M.,Ottmann, C. (deposition date: 2019-02-04, release date: 2020-05-13, Last modification date: 2024-01-24) |
Primary citation | Wolter, M.,de Vink, P.,Neves, J.F.,Srdanovic, S.,Higuchi, Y.,Kato, N.,Wilson, A.,Landrieu, I.,Brunsveld, L.,Ottmann, C. Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142:11772-11783, 2020 Cited by PubMed: 32501683DOI: 10.1021/jacs.0c02151 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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