6QDT

Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide

Summary for 6QDT

• Entry DOI: 10.2210/pdb6qdt/pdb
• Descriptor: 14-3-3 protein sigma, Rap guanine nucleotide exchange factor 2, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: neuron regeneration, ppi, phosphorylation, chaperone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28062.88

Authors

Andrei, S.A.,Kaplan, A.,Fournier, A.E.,Ottman, C. (deposition date: 2019-01-02, release date: 2020-01-29, Last modification date: 2024-01-24)

• Primary citation: Kaplan, A.,Andrei, S.A.,van Regteren Altena, A.,Simas, T.,Banerjee, S.L.,Kato, N.,Bisson, N.,Higuchi, Y.,Ottmann, C.,Fournier, A.E.; Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.; Cell Chem Biol, 27:657-667.e6, 2020; PubMed: 32220335; DOI: 10.1016/j.chembiol.2020.02.010

Experimental method

X-RAY DIFFRACTION (1.702 Å)