6QDT
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (B) | Rap guanine nucleotide exchange factor 2 | polymer | 12 | 1329.5 | 1 | UniProt (Q9Y4G8) | Homo sapiens | Cyclic nucleotide ras GEF,CNrasGEF,Neural RAP guanine nucleotide exchange protein,nRap GEP,PDZ domain-containing guanine nucleotide exchange factor 1,PDZ-GEF1,RA-GEF-1,Ras/Rap1-associating GEF-1 |
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F, G, H, I (A) | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 415 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
B: 588 - 599 (UniProt: Q9Y4G8)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 588 | Phe 746 | acetylation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27872.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 190.5 | |
| All* | Total formula weight | 28062.9 |
