4NGE
 
 | | Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) | | Descriptor: | ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ... | | Authors: | King, J.V, Liang, W.G, Tang, W.J. | | Deposit date: | 2013-11-01 | | Release date: | 2014-05-14 | | Last modified: | 2014-07-23 | | Method: | X-RAY DIFFRACTION (2.704 Å) | | Cite: | Molecular basis of substrate recognition and degradation by human presequence protease.
Structure, 22, 2014
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4XXD
 | | Crystal Structure of mid-region amyloid beta capture by solanezumab | | Descriptor: | Amyloid-beta fragment, Fab Heavy Chain, Fab Light Chain | | Authors: | Hermans, S.J, Crespi, G.A.N, Parker, M.W, Miles, L.A. | | Deposit date: | 2015-01-30 | | Release date: | 2015-04-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies.
Sci Rep, 5, 2015
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1OWT
 | | Structure of the Alzheimer's disease amyloid precursor protein copper binding domain | | Descriptor: | Amyloid beta A4 protein | | Authors: | Barnham, K.J, McKinstry, W.J, Multhaup, G, Galatis, D, Morton, C.J, Curtain, C.C, Williamson, N.A, White, A.R, Hinds, M.G, Norton, R.S, Beyreuther, K, Masters, C.L, Parker, M.W, Cappai, R. | | Deposit date: | 2003-03-30 | | Release date: | 2003-05-13 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain. A REGULATOR OF NEURONAL COPPER HOMEOSTASIS.
J.Biol.Chem., 278, 2003
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6XOV
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6RHY
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4PWQ
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6YHF
 | | Solution NMR Structure of APP TMD | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Silber, M, Muhle-Goll, C. | | Deposit date: | 2020-03-29 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
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6YHO
 | | Solution NMR Structure of APP G38P mutant TM | | Descriptor: | Amyloid-beta precursor protein G38P mutant | | Authors: | Silber, M, Muhle-Goll, C. | | Deposit date: | 2020-03-30 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
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6YHP
 | | Solution NMR Structure of APP V44M mutant TMD | | Descriptor: | Amyloid-beta precursor protein V44M mutant | | Authors: | Silber, M, Muhle-Goll, C. | | Deposit date: | 2020-03-30 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
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6YHX
 | | Solution NMR Structure of APP I45T mutant TMD | | Descriptor: | Amyloid-beta precursor protein I45T mutant | | Authors: | Silber, M, Muhle-Goll, C. | | Deposit date: | 2020-03-31 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
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6YHI
 | | Solution NMR Structure of APP G38L mutant TMD | | Descriptor: | Amyloid-beta precursor protein G38L mutant | | Authors: | Silber, M, Muhle-Goll, C. | | Deposit date: | 2020-03-30 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
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6SHS
 | | Abeta fibril (Morphology I) | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Kollmer, M, Fandrich, M. | | Deposit date: | 2019-08-08 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM structure and polymorphism of A beta amyloid fibrils purified from Alzheimer's brain tissue.
Nat Commun, 10, 2019
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6SZF
 | | Solution structure of the amyloid beta-peptide (1-42) | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. | | Deposit date: | 2019-10-02 | | Release date: | 2020-10-14 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study.
Pharmaceuticals, 14, 2021
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6TI7
 | | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | | Deposit date: | 2019-11-21 | | Release date: | 2020-07-22 | | Last modified: | 2023-06-14 | | Method: | SOLID-STATE NMR | | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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4OJF
 | | Humanised 3D6 Fab complexed to amyloid beta 1-8 | | Descriptor: | Amyloid beta A4 protein, Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain | | Authors: | Miles, L.A, Crespi, G.A.N, Parker, M.W. | | Deposit date: | 2014-01-21 | | Release date: | 2015-01-28 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.998 Å) | | Cite: | Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta
ACTA CRYSTALLOGR.,SECT.F, 70, 2014
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4ONG
 | | Fab fragment of 3D6 in complex with amyloid beta 1-40 | | Descriptor: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... | | Authors: | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | Deposit date: | 2014-01-28 | | Release date: | 2014-06-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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6TI5
 | | A New Structural Model of Abeta(1-40) Fibrils | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Bertini, I, Gonnelli, L, Luchinat, C, Mao, J, Nesi, A. | | Deposit date: | 2019-11-21 | | Release date: | 2020-07-22 | | Last modified: | 2023-06-14 | | Method: | SOLID-STATE NMR | | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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4ONF
 | | Fab fragment of 3D6 in complex with amyloid beta 1-7 | | Descriptor: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein | | Authors: | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | Deposit date: | 2014-01-28 | | Release date: | 2014-06-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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5AM8
 | | Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, ... | | Authors: | Masuyer, G, Larmuth, K.M, Douglas, R.G, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2015-03-10 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
FEBS J., 283, 2016
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5AMB
 | | Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMYLOID BETA A4 PROTEIN, ANGIOTENSIN-CONVERTING ENZYME, ... | | Authors: | Masuyer, G, Larmuth, K.M, Douglas, R.G, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2015-03-10 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
FEBS J., 283, 2016
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6TI6
 | | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | | Descriptor: | Amyloid-beta precursor protein | | Authors: | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | | Deposit date: | 2019-11-21 | | Release date: | 2020-07-22 | | Last modified: | 2023-06-14 | | Method: | SOLID-STATE NMR | | Cite: | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
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4PQD
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5BUO
 | | A receptor molecule | | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACETATE ION, Amyloid beta A4 protein, ... | | Authors: | Gao, C, Crespi, G.A.N, Gorman, M.A, Nero, T.L, Parker, M.W, Miles, L.A. | | Deposit date: | 2015-06-04 | | Release date: | 2016-07-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | NULL
To Be Published
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1QXC
 | | NMR structure of the fragment 25-35 of beta amyloid peptide in 20/80 v:v hexafluoroisopropanol/water mixture | | Descriptor: | 11-mer peptide from Amyloid beta A4 protein | | Authors: | D'Ursi, A.M, Armenante, M.R, Guerrini, R, Salvadori, S, Sorrentino, G, Picone, D. | | Deposit date: | 2003-09-05 | | Release date: | 2004-09-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of amyloid beta-peptide (25-35) in different media
J.Med.Chem., 47, 2004
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1QWP
 | | NMR analysis of 25-35 fragment of beta amyloid peptide | | Descriptor: | 11-mer peptide from Amyloid beta A4 protein | | Authors: | D'Ursi, A.M, Armenante, M.R, Guerrini, R, Salvadori, S, Sorrentino, G, Picone, D. | | Deposit date: | 2003-09-03 | | Release date: | 2004-09-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of amyloid beta-peptide (25-35) in different media
J.Med.Chem., 47, 2004
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