4OJF

Humanised 3D6 Fab complexed to amyloid beta 1-8

Summary for 4OJF

• Entry DOI: 10.2210/pdb4ojf/pdb
• Related: 4HIX
• Descriptor: Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain, Amyloid beta A4 protein, ... (4 entities in total)
• Functional Keywords: amyloid, bapineuzumab, 3d6, alzheimer's disease, immunoglobulin, immunotherapy, amyloid beta, immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 3
• Total formula weight: 49274.90

Authors

Miles, L.A.,Crespi, G.A.N.,Parker, M.W. (deposition date: 2014-01-21, release date: 2015-01-28, Last modification date: 2023-11-08)

• Primary citation: Crespi, G.A.N.,Ascher, D.B.,Parker, M.W.,Miles, L.A.; Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta; ACTA CRYSTALLOGR.,SECT.F, 70:374-377, 2014; PubMed: 24598931; DOI: 10.1107/S2053230X14001642

Experimental method

X-RAY DIFFRACTION (1.998 Å)