4HIX

Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide

Summary for 4HIX

• Entry DOI: 10.2210/pdb4hix/pdb
• Related: 2IPU 3BAE
• Descriptor: Humanized 3D6 Fab heavy chain, Humanized 3D6 Fab light chain, Beta-amyloid protein 40, ... (4 entities in total)
• Functional Keywords: immunoglobulin, immunotherapy candidate, amyloid beta peptide, protein fibril-immune system complex, protein fibril/immune system
• Biological source: homo Sapiens, Mus musculus (human, mouse); More
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 3
• Total formula weight: 51694.54

Authors

Miles, L.A.,Crespi, G.A.N.,Parker, M.W. (deposition date: 2012-10-12, release date: 2013-03-13, Last modification date: 2014-03-19)

• Primary citation: Miles, L.A.,Crespi, G.A.,Doughty, L.,Parker, M.W.; Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.; Sci Rep, 3:1302-1302, 2013; PubMed: 23416764; DOI: 10.1038/srep01302

Experimental method

X-RAY DIFFRACTION (2.204 Å)