2P0F
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![BU of 2p0f by Molmil](/molmil-images/mine/2p0f) | ArhGAP9 PH domain in complex with Ins(1,3,5)P3 | Descriptor: | PHOSPHATE ION, Rho GTPase-activating protein 9 | Authors: | Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F. | Deposit date: | 2007-02-28 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9. J.Biol.Chem., 282, 2007
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1ZVD
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![BU of 1zvd by Molmil](/molmil-images/mine/1zvd) | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain | Descriptor: | PHOSPHATE ION, SODIUM ION, Smad ubiquitination regulatory factor 2 | Authors: | Ogunjimi, A.A, Briant, D.J, Pece-Barbara, N, Le Roy, C, Di Guglielmo, G.M, Kavsak, P, Rasmussen, R.K, Seet, B.T, Sicheri, F, Wrana, J.L. | Deposit date: | 2005-06-01 | Release date: | 2005-08-09 | Last modified: | 2011-09-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain. Mol.Cell, 19, 2005
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2P0D
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![BU of 2p0d by Molmil](/molmil-images/mine/2p0d) | ArhGAP9 PH domain in complex with Ins(1,4,5)P3 | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Rho GTPase-activating protein 9 | Authors: | Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F. | Deposit date: | 2007-02-28 | Release date: | 2007-03-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.811 Å) | Cite: | Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9. J.Biol.Chem., 282, 2007
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4K25
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![BU of 4k25 by Molmil](/molmil-images/mine/4k25) | Crystal Structure of yeast Qri7 homodimer | Descriptor: | CALCIUM ION, Probable tRNA threonylcarbamoyladenosine biosynthesis protein QRI7, mitochondrial, ... | Authors: | Neculai, D, Wan, L, Mao, D.Y, Sicheri, F. | Deposit date: | 2013-04-08 | Release date: | 2013-05-08 | Last modified: | 2013-08-07 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res., 41, 2013
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2HEL
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![BU of 2hel by Molmil](/molmil-images/mine/2hel) | |
2A1A
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![BU of 2a1a by Molmil](/molmil-images/mine/2a1a) | PKR kinase domain-eIF2alpha Complex | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | Deposit date: | 2005-06-19 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR. Cell(Cambridge,Mass.), 122, 2005
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2QNJ
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![BU of 2qnj by Molmil](/molmil-images/mine/2qnj) | |
6CRN
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![BU of 6crn by Molmil](/molmil-images/mine/6crn) | Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | Deposit date: | 2018-03-19 | Release date: | 2019-01-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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8T7I
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![BU of 8t7i by Molmil](/molmil-images/mine/8t7i) | Structure of the S1CE variant of Fab F1 (FabS1CE-F1) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, S1CE variant of Fab F1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-06-20 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T7G
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![BU of 8t7g by Molmil](/molmil-images/mine/8t7g) | Structure of the CK variant of Fab F1 (FabC-F1) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, CK variant of Fab F1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-06-20 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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6BVA
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![BU of 6bva by Molmil](/molmil-images/mine/6bva) | |
6BYH
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![BU of 6byh by Molmil](/molmil-images/mine/6byh) | |
6C16
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![BU of 6c16 by Molmil](/molmil-images/mine/6c16) | |
6D6I
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![BU of 6d6i by Molmil](/molmil-images/mine/6d6i) | Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13 | Descriptor: | Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1, Ubv.V1.1 | Authors: | Ceccarelli, D.F, Garg, P, Keszei, A, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-21 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.551 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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6CPM
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![BU of 6cpm by Molmil](/molmil-images/mine/6cpm) | Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | Deposit date: | 2018-03-13 | Release date: | 2019-01-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.011 Å) | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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8TS5
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![BU of 8ts5 by Molmil](/molmil-images/mine/8ts5) | Structure of the apo FabS1C_C1 | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L.L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-08-10 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8TRT
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![BU of 8trt by Molmil](/molmil-images/mine/8trt) | Structure of the EphA2 CRD bound to FabS1CE_C1, monoclinic form | Descriptor: | CHLORIDE ION, Ephrin type-A receptor 2, S1CE variant of Fab C1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-08-10 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8TRS
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![BU of 8trs by Molmil](/molmil-images/mine/8trs) | Structure of the EphA2 CRD bound to FabS1CE_C1, trigonal form | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-08-10 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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6D4P
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![BU of 6d4p by Molmil](/molmil-images/mine/6d4p) | Ube2D1 in complex with ubiquitin variant Ubv.D1.1 | Descriptor: | Ubiquitin Variant Ubv.D1.1, Ubiquitin-conjugating enzyme E2 D1 | Authors: | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-18 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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6D68
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![BU of 6d68 by Molmil](/molmil-images/mine/6d68) | Ube2G1 in complex with ubiquitin variant Ubv.G1.1 | Descriptor: | Ubiquitin-conjugating enzyme E2 G1, Ubv.G1.1 | Authors: | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-20 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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2PBC
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![BU of 2pbc by Molmil](/molmil-images/mine/2pbc) | FK506-binding protein 2 | Descriptor: | DI(HYDROXYETHYL)ETHER, FK506-binding protein 2 | Authors: | Walker, J.R, Neculai, D, Davis, T, Butler-Cole, C, Sicheri, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-03-28 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of FK506-Binding Protein 2 To be Published
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6CAD
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![BU of 6cad by Molmil](/molmil-images/mine/6cad) | Crystal structure of RAF kinase domain bound to the inhibitor 2a | Descriptor: | 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Serine/threonine-protein kinase B-raf | Authors: | Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Liu, X, Chen, Y.-C, Prakash, G.K.S, Zhang, C, SIcheri, F. | Deposit date: | 2018-01-30 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Effects of rigidity on the selectivity of protein kinase inhibitors. Eur J Med Chem, 146, 2018
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6BXI
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![BU of 6bxi by Molmil](/molmil-images/mine/6bxi) | X-ray crystal structure of NDR1 kinase domain | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase 38 | Authors: | Xiong, S, Sicheri, F. | Deposit date: | 2017-12-18 | Release date: | 2018-08-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure, 26, 2018
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6DGF
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![BU of 6dgf by Molmil](/molmil-images/mine/6dgf) | Ubiquitin Variant bound to USP2 | Descriptor: | Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 2, ... | Authors: | Manczyk, N, Sicheri, F. | Deposit date: | 2018-05-17 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases. J. Mol. Biol., 431, 2019
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3RZ3
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![BU of 3rz3 by Molmil](/molmil-images/mine/3rz3) | Human Cdc34 E2 in complex with CC0651 inhibitor | Descriptor: | 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin-conjugating enzyme E2 R1 | Authors: | Ceccarelli, D.F, Webb, D.R, Sicheri, F. | Deposit date: | 2011-05-11 | Release date: | 2011-07-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme Cell(Cambridge,Mass.), 145, 2011
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