2QNJ

Kinase and Ubiquitin-associated domains of MARK3/Par-1

Summary for 2QNJ

Entry DOI	10.2210/pdb2qnj/pdb
Descriptor	MAP/microtubule affinity-regulating kinase 3 (2 entities in total)
Functional Keywords	serine/threonine protein kinase, ubiquitin-associated domain, mark, par-1, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane ; Peripheral membrane protein : P27448
Total number of polymer chains	2
Total formula weight	75337.13
Authors	Murphy, J.M.,Ceccarelli, D.F.J.,Sicheri, F.,Pawson, T. (deposition date: 2007-07-18, release date: 2007-09-04, Last modification date: 2023-08-30)
Primary citation	Murphy, J.M.,Korzhnev, D.M.,Ceccarelli, D.F.,Briant, D.J.,Zarrine-Afsar, A.,Sicheri, F.,Kay, L.E.,Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain Proc.Natl.Acad.Sci.Usa, 104:14336-14341, 2007 Cited by PubMed: 17726107 DOI: 10.1073/pnas.0703012104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation