2QNJ
Kinase and Ubiquitin-associated domains of MARK3/Par-1
Summary for 2QNJ
Entry DOI | 10.2210/pdb2qnj/pdb |
Descriptor | MAP/microtubule affinity-regulating kinase 3 (2 entities in total) |
Functional Keywords | serine/threonine protein kinase, ubiquitin-associated domain, mark, par-1, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Peripheral membrane protein : P27448 |
Total number of polymer chains | 2 |
Total formula weight | 75337.13 |
Authors | Murphy, J.M.,Ceccarelli, D.F.J.,Sicheri, F.,Pawson, T. (deposition date: 2007-07-18, release date: 2007-09-04, Last modification date: 2023-08-30) |
Primary citation | Murphy, J.M.,Korzhnev, D.M.,Ceccarelli, D.F.,Briant, D.J.,Zarrine-Afsar, A.,Sicheri, F.,Kay, L.E.,Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain Proc.Natl.Acad.Sci.Usa, 104:14336-14341, 2007 Cited by PubMed: 17726107DOI: 10.1073/pnas.0703012104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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