8TS5

Structure of the apo FabS1C_C1

Summary for 8TS5

• Entry DOI: 10.2210/pdb8ts5/pdb
• Related: 8TRS 8TRT 8TRV
• Descriptor: S1C variant of Fab C1 heavy chain, S1C variant of Fab C1 light chain, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (9 entities in total)
• Functional Keywords: cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 97086.37

Authors

Singer, A.U.,Bruce, H.A.,Blazer, L.L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-08-10, release date: 2023-11-22, Last modification date: 2024-01-10)

• Primary citation: Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S.; Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.; Protein Sci., 33:e4824-e4824, 2024; PubMed: 37945533; DOI: 10.1002/pro.4824

Experimental method

X-RAY DIFFRACTION (2.1 Å)