8TRV

Structure of the EphA2 LBDCRD bound to FabS1C_C1

Summary for 8TRV

• Entry DOI: 10.2210/pdb8trv/pdb
• Related: 8TRS 8TRT 8TRV
• Descriptor: Ephrin type-A receptor 2, S1C variant of Fab_C1 heavy chain, S1C variant of Fab_C1 light chain, ... (7 entities in total)
• Functional Keywords: cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 163542.76

Authors

Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-08-10, release date: 2024-07-17)

• Primary citation: Adams, J.J.,Bruce, H.A.,Ploder, L.,Garcia, J.,Khutoreskaya, G.,Jarvik, N.,Costa, L.E.,Gorelik, M.,Pot, I.,Sicheri, F.,Blazer, L.L.,Singer, A.U.,Sidhu, S.S.; Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation; To be Published,

Experimental method

X-RAY DIFFRACTION (3.25 Å)