8TRS

Structure of the EphA2 CRD bound to FabS1CE_C1, trigonal form

Summary for 8TRS

Entry DOI	10.2210/pdb8trs/pdb
Related	8TRS 8TRT 8TRV
Descriptor	S1CE variant of Fab C1 heavy chain, S1CE variant of Fab C1 light chain, Ephrin type-A receptor 2, ... (8 entities in total)
Functional Keywords	cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	63826.23
Authors	Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-08-10, release date: 2023-11-22, Last modification date: 2024-01-10)
Primary citation	Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S. Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33:e4824-e4824, 2024 Cited by PubMed: 37945533 DOI: 10.1002/pro.4824 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation