8TRT
Structure of the EphA2 CRD bound to FabS1CE_C1, monoclinic form
Summary for 8TRT
Entry DOI | 10.2210/pdb8trt/pdb |
Related | 8TRS 8TRT 8TRV |
Descriptor | S1CE variant of Fab C1 heavy chain, S1CE variant of Fab C1 light chain, Ephrin type-A receptor 2, ... (6 entities in total) |
Functional Keywords | cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 122744.60 |
Authors | Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-08-10, release date: 2023-11-22, Last modification date: 2024-01-10) |
Primary citation | Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S. Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33:e4824-e4824, 2024 Cited by PubMed: 37945533DOI: 10.1002/pro.4824 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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