6CAD

Crystal structure of RAF kinase domain bound to the inhibitor 2a

Summary for 6CAD

• Entry DOI: 10.2210/pdb6cad/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: braf inhibitors, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 65444.81

Authors

Maisonneuve, P.,Kurinov, I.,Assadieskandar, A.,Yu, C.,Liu, X.,Chen, Y.-C.,Prakash, G.K.S.,Zhang, C.,SIcheri, F. (deposition date: 2018-01-30, release date: 2018-02-21, Last modification date: 2023-10-04)

• Primary citation: Assadieskandar, A.,Yu, C.,Maisonneuve, P.,Liu, X.,Chen, Y.C.,Prakash, G.K.S.,Kurinov, I.,Sicheri, F.,Zhang, C.; Effects of rigidity on the selectivity of protein kinase inhibitors.; Eur J Med Chem, 146:519-528, 2018; PubMed: 29407977; DOI: 10.1016/j.ejmech.2018.01.053

Experimental method

X-RAY DIFFRACTION (2.55 Å)