8T7I

Structure of the S1CE variant of Fab F1 (FabS1CE-F1)

Summary for 8T7I

Entry DOI	10.2210/pdb8t7i/pdb
Related	8T7F 8T7G
Descriptor	S1CE variant of Fab F1 heavy chain, S1CE variant of Fab F1 light chain, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	enhanced crystallization, epha2 binding, expressed protein, fab, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	49026.90
Authors	Singer, A.U.,Bruce, H.A.,Enderle, L.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-06-20, release date: 2023-11-22, Last modification date: 2024-01-10)
Primary citation	Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S. Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33:e4824-e4824, 2024 Cited by PubMed: 37945533 DOI: 10.1002/pro.4824 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation