3RZ3

Human Cdc34 E2 in complex with CC0651 inhibitor

Summary for 3RZ3

• Entry DOI: 10.2210/pdb3rz3/pdb
• Related: 2OB4
• Descriptor: Ubiquitin-conjugating enzyme E2 R1, 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid (3 entities in total)
• Functional Keywords: ubiquitin conjugating enzyme domain, e2 domain, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P49427
• Total number of polymer chains: 4
• Total formula weight: 84807.14

Authors

Ceccarelli, D.F.,Webb, D.R.,Sicheri, F. (deposition date: 2011-05-11, release date: 2011-07-06, Last modification date: 2023-09-13)

• Primary citation: Ceccarelli, D.F.,Tang, X.,Pelletier, B.,Orlicky, S.,Xie, W.,Plantevin, V.,Neculai, D.,Chou, Y.C.,Ogunjimi, A.,Al-Hakim, A.,Varelas, X.,Koszela, J.,Wasney, G.A.,Vedadi, M.,Dhe-Paganon, S.,Cox, S.,Xu, S.,Lopez-Girona, A.,Mercurio, F.,Wrana, J.,Durocher, D.,Meloche, S.,Webb, D.R.,Tyers, M.,Sicheri, F.; An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme; Cell(Cambridge,Mass.), 145:1075-1087, 2011; PubMed: 21683433; DOI: 10.1016/j.cell.2011.05.039

Experimental method

X-RAY DIFFRACTION (2.3 Å)