3RZ3
Human Cdc34 E2 in complex with CC0651 inhibitor
Summary for 3RZ3
Entry DOI | 10.2210/pdb3rz3/pdb |
Related | 2OB4 |
Descriptor | Ubiquitin-conjugating enzyme E2 R1, 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid (3 entities in total) |
Functional Keywords | ubiquitin conjugating enzyme domain, e2 domain, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49427 |
Total number of polymer chains | 4 |
Total formula weight | 84807.14 |
Authors | Ceccarelli, D.F.,Webb, D.R.,Sicheri, F. (deposition date: 2011-05-11, release date: 2011-07-06, Last modification date: 2023-09-13) |
Primary citation | Ceccarelli, D.F.,Tang, X.,Pelletier, B.,Orlicky, S.,Xie, W.,Plantevin, V.,Neculai, D.,Chou, Y.C.,Ogunjimi, A.,Al-Hakim, A.,Varelas, X.,Koszela, J.,Wasney, G.A.,Vedadi, M.,Dhe-Paganon, S.,Cox, S.,Xu, S.,Lopez-Girona, A.,Mercurio, F.,Wrana, J.,Durocher, D.,Meloche, S.,Webb, D.R.,Tyers, M.,Sicheri, F. An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme Cell(Cambridge,Mass.), 145:1075-1087, 2011 Cited by PubMed: 21683433DOI: 10.1016/j.cell.2011.05.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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