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PDB: 27 results

8VM2
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BU of 8vm2 by Molmil
Crystal Structure of NRAS Q61K bound to GTP
Descriptor: GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M.
Deposit date:2024-01-12
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
Eur J Cell Biol, 103, 2024
7SCX
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BU of 7scx by Molmil
KRAS full-length G12V in complex with RGL1 Ras association domain
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
Authors:Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B.
Deposit date:2021-09-29
Release date:2022-05-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.
J.Mol.Biol., 434, 2022
7SCW
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BU of 7scw by Molmil
KRAS full length wild-type in complex with RGL1 Ras association domain
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
Authors:Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B.
Deposit date:2021-09-29
Release date:2022-05-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.
J.Mol.Biol., 434, 2022
7RSC
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BU of 7rsc by Molmil
NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B.
Deposit date:2021-08-11
Release date:2021-09-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
7RSE
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BU of 7rse by Molmil
NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B.
Deposit date:2021-08-11
Release date:2021-09-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
6W4E
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BU of 6w4e by Molmil
NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, ...
Authors:Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M.
Deposit date:2020-03-10
Release date:2020-04-15
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
Angew.Chem.Int.Ed.Engl., 59, 2020
6W4F
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BU of 6w4f by Molmil
NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M.
Deposit date:2020-03-10
Release date:2020-04-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
Angew.Chem.Int.Ed.Engl., 59, 2020
6OS4
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BU of 6os4 by Molmil
Calmodulin in complex with farnesyl cysteine methyl ester
Descriptor: CALCIUM ION, Calmodulin-1, s-farnesyl-l-cysteine methyl ester
Authors:Grant, B.M.M, Enomoto, M, Lee, K.Y, Back, S.I, Gebregiworgis, T, Ishiyama, N, Ikura, M, Marshall, C.
Deposit date:2019-05-01
Release date:2020-04-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety.
Sci.Signal., 13, 2020
6PTS
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BU of 6pts by Molmil
NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state A)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Fang, Z, Lee, K, Gasmi-Seabrook, G, Ikura, M, Marshall, C.B.
Deposit date:2019-07-16
Release date:2020-05-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PTW
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BU of 6ptw by Molmil
NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state B)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Fang, Z, Lee, K, Gasmi-Seabrook, G, Ikura, M, Marshall, C.B.
Deposit date:2019-07-16
Release date:2020-05-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
Proc.Natl.Acad.Sci.USA, 117, 2020
2J5I
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BU of 2j5i by Molmil
Crystal Structure of Hydroxycinnamoyl-CoA Hydratase-Lyase
Descriptor: P-HYDROXYCINNAMOYL COA HYDRATASE/LYASE
Authors:Leonard, P.M, Brzozowski, A.M, Lebedev, A, Marshall, C.M, Smith, D.J, Verma, C.S, Walton, N.J, Grogan, G.
Deposit date:2006-09-18
Release date:2006-12-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8 A Resolution Structure of Hydroxycinnamoyl- Coenzyme a Hydratase-Lyase (Hchl) from Pseudomonas Fluorescens, an Enzyme that Catalyses the Transformation of Feruloyl-Coenzyme a to Vanillin.
Acta Crystallogr.,Sect.D, 62, 2006
2K86
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BU of 2k86 by Molmil
Solution Structure of FOXO3a Forkhead domain
Descriptor: Forkhead box protein O3
Authors:Wang, F, Marshall, C.B, Li, G, Plevin, M.J, Ikura, M.
Deposit date:2008-09-02
Release date:2008-10-14
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
J.Mol.Biol., 384, 2008
1L5A
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BU of 1l5a by Molmil
Crystal Structure of VibH, an NRPS Condensation Enzyme
Descriptor: amide synthase
Authors:Keating, T.A, Marshall, C.G, Walsh, C.T, Keating, A.E.
Deposit date:2002-03-06
Release date:2002-06-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.
Nat.Struct.Biol., 9, 2002
2MSC
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BU of 2msc by Molmil
NMR data-driven model of GTPase KRas-GDP tethered to a lipid-bilayer nanodisc
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Mazhab-Jafari, M, Stathopoulos, P, Marshall, C, Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
2MSD
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BU of 2msd by Molmil
NMR data-driven model of GTPase KRas-GNP tethered to a lipid-bilayer nanodisc
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Mazhab-Jafari, M, Stathopoulos, P, Marshall, C, Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
2MSE
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BU of 2mse by Molmil
NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Mazhab-Jafari, M, Stathopoulos, P, Marshall, C, Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
4O2R
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BU of 4o2r by Molmil
Structure of Mus musculus Rheb G63V mutant bound to GDP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M.
Deposit date:2013-12-17
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J.Biol.Chem., 289, 2014
4O25
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BU of 4o25 by Molmil
Structure of Wild Type Mus musculus Rheb bound to GTP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M.
Deposit date:2013-12-16
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J.Biol.Chem., 289, 2014
4O2L
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BU of 4o2l by Molmil
Structure of Mus musculus Rheb G63A mutant bound to GTP
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GTP-binding protein Rheb, ...
Authors:Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M.
Deposit date:2013-12-17
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J.Biol.Chem., 289, 2014
6CC9
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BU of 6cc9 by Molmil
NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc
Descriptor: (2R,4S)-4-[(5-bromo-1H-indole-3-carbonyl)amino]-2-[(4-chlorophenyl)methyl]piperidin-1-ium, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, ...
Authors:Fang, Z, Marshall, C.B, Nishikawa, T, Gossert, A.D, Jansen, J.M, Jahnke, W, Ikura, M.
Deposit date:2018-02-06
Release date:2018-09-05
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.
Cell Chem Biol, 25, 2018
6CCX
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BU of 6ccx by Molmil
NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc
Descriptor: (2R,4S)-4-[(5-bromo-1H-indole-3-carbonyl)amino]-2-[(4-chlorophenyl)methyl]piperidin-1-ium, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, ...
Authors:Fang, Z, Marshall, C.B, Nishikawa, T, Gossert, A.D, Jansen, J.M, Jahnke, W, Ikura, M.
Deposit date:2018-02-07
Release date:2018-09-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.
Cell Chem Biol, 25, 2018
2LQH
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BU of 2lqh by Molmil
NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation)
Descriptor: CREB-binding protein, Forkhead box O3
Authors:Wang, F, Marshall, C.B, Yamamoto, K, Li, G.B, Gasmi-Seabrook, G.M.C, Okada, H, Mak, T.W, Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LQI
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BU of 2lqi by Molmil
NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2l3b conformation)
Descriptor: CREB-binding protein, Forkhead box O3
Authors:Wang, F, Marshall, C.B, Yamamoto, K, Li, G.B, Gasmi-Seabrook, G.M.C, Okada, H, Mak, T.W, Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
6CCH
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BU of 6cch by Molmil
NMR data-driven model of GTPase KRas-GMPPNP tethered to a nanodisc (E3 state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ...
Authors:Fang, Z, Marshall, C.B, Nishikawa, T, Gossert, A.D, Jansen, J.M, Jahnke, W, Ikura, M.
Deposit date:2018-02-07
Release date:2018-08-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.
Cell Chem Biol, 25, 2018
5WI4
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BU of 5wi4 by Molmil
CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH ARHGEF2
Descriptor: Dynein light chain Tctex-type 1,Rho guanine nucleotide exchange factor 2, SULFATE ION
Authors:Balan, M, Ishiyama, N, Marshall, C.B, Ikura, M.
Deposit date:2017-07-18
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
Sci Signal, 10, 2017

 

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