6CCX
NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc
Summary for 6CCX
Entry DOI | 10.2210/pdb6ccx/pdb |
NMR Information | BMRB: 30403 |
Descriptor | Apolipoprotein A-I, GTPase KRas, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (7 entities in total) |
Functional Keywords | protein-bilayer-compound complex, membrane protein-oncoprotein complex, membrane protein/oncoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 131749.63 |
Authors | Fang, Z.,Marshall, C.B.,Nishikawa, T.,Gossert, A.D.,Jansen, J.M.,Jahnke, W.,Ikura, M. (deposition date: 2018-02-07, release date: 2018-09-05, Last modification date: 2024-05-15) |
Primary citation | Fang, Z.,Marshall, C.B.,Nishikawa, T.,Gossert, A.D.,Jansen, J.M.,Jahnke, W.,Ikura, M. Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site. Cell Chem Biol, 25:1327-1336.e4, 2018 Cited by PubMed: 30122370DOI: 10.1016/j.chembiol.2018.07.009 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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