Solution Structure of FOXO3a Forkhead domain

Summary for 2K86

DescriptorForkhead box protein O3 (1 entity in total)
Functional Keywordsforkhead, winged-helix, dna binding domain, activator, apoptosis, chromosomal rearrangement, cytoplasm, dna-binding, nucleus, phosphoprotein, proto-oncogene, transcription, transcription regulation, dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytosol O43524
Total number of polymer chains1
Total molecular weight11706.14
Wang, F.,Marshall, C.B.,Li, G.,Plevin, M.J.,Ikura, M. (deposition date: 2008-09-02, release date: 2008-10-14, Last modification date: 2011-07-13)
Primary citation
Wang, F.,Marshall, C.B.,Yamamoto, K.,Li, G.Y.,Plevin, M.J.,You, H.,Mak, T.W.,Ikura, M.
Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
J.Mol.Biol., 384:590-603, 2008
PubMed: 18824006 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.09.025
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers155.2%8.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2k86
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Molmil generated image of 2k86
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Molmil generated image of 2k86
rotated about y axis by 90°