2K86

Solution Structure of FOXO3a Forkhead domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WKNSIRH

Chain	Residue	Details
A	TRP206-HIS212

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	94
Details	DNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089

Chain	Residue	Details
A	TRP157-ALA251

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:17711846

Chain	Residue	Details
A	THR179

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:16751106

Chain	Residue	Details
A	SER209

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:21329882

Chain	Residue	Details
A	SER215

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:22820736

Chain	Residue	Details
A	LYS230

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVH4

Chain	Residue	Details
A	LYS242

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