7RSE

NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc

Summary for 7RSE

• Entry DOI: 10.2210/pdb7rse/pdb
• NMR Information: BMRB: 30734
• Descriptor: GTPase KRas, Apolipoprotein A-I, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (6 entities in total)
• Functional Keywords: nanodisc, oncoprotein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 189151.73

Authors

Lee, K.,Enomoto, M.,Gebregiworgis, T.,Gasmi-Seabrook, G.M.,Ikura, M.,Marshall, C.B. (deposition date: 2021-08-11, release date: 2021-09-22, Last modification date: 2023-06-14)

• Primary citation: Lee, K.Y.,Enomoto, M.,Gebregiworgis, T.,Gasmi-Seabrook, G.M.C.,Ikura, M.,Marshall, C.B.; Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.; Chem Sci, 12:12827-12837, 2021; PubMed: 34703570; DOI: 10.1039/d1sc03484g

Experimental method

SOLUTION NMR