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7RSE

NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0001934biological_processpositive regulation of protein phosphorylation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0008283biological_processcell population proliferation
A0008542biological_processvisual learning
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010467biological_processgene expression
A0010628biological_processpositive regulation of gene expression
A0012505cellular_componentendomembrane system
A0014009biological_processglial cell proliferation
A0016020cellular_componentmembrane
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0021897biological_processforebrain astrocyte development
A0030036biological_processactin cytoskeleton organization
A0030857biological_processnegative regulation of epithelial cell differentiation
A0032228biological_processregulation of synaptic transmission, GABAergic
A0035022biological_processpositive regulation of Rac protein signal transduction
A0035914biological_processskeletal muscle cell differentiation
A0043495molecular_functionprotein-membrane adaptor activity
A0043524biological_processnegative regulation of neuron apoptotic process
A0044877molecular_functionprotein-containing complex binding
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048873biological_processhomeostasis of number of cells within a tissue
A0051146biological_processstriated muscle cell differentiation
A0051402biological_processneuron apoptotic process
A0060252biological_processpositive regulation of glial cell proliferation
A0060441biological_processepithelial tube branching involved in lung morphogenesis
A0060509biological_processtype I pneumocyte differentiation
B0000139cellular_componentGolgi membrane
B0000165biological_processMAPK cascade
B0001934biological_processpositive regulation of protein phosphorylation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0007165biological_processsignal transduction
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0008542biological_processvisual learning
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010467biological_processgene expression
B0010628biological_processpositive regulation of gene expression
B0012505cellular_componentendomembrane system
B0014009biological_processglial cell proliferation
B0016020cellular_componentmembrane
B0016601biological_processRac protein signal transduction
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0021897biological_processforebrain astrocyte development
B0030036biological_processactin cytoskeleton organization
B0030857biological_processnegative regulation of epithelial cell differentiation
B0032228biological_processregulation of synaptic transmission, GABAergic
B0035022biological_processpositive regulation of Rac protein signal transduction
B0035914biological_processskeletal muscle cell differentiation
B0043495molecular_functionprotein-membrane adaptor activity
B0043524biological_processnegative regulation of neuron apoptotic process
B0044877molecular_functionprotein-containing complex binding
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048873biological_processhomeostasis of number of cells within a tissue
B0051146biological_processstriated muscle cell differentiation
B0051402biological_processneuron apoptotic process
B0060252biological_processpositive regulation of glial cell proliferation
B0060441biological_processepithelial tube branching involved in lung morphogenesis
B0060509biological_processtype I pneumocyte differentiation
D0005576cellular_componentextracellular region
D0006869biological_processlipid transport
D0008289molecular_functionlipid binding
D0042157biological_processlipoprotein metabolic process
E0005576cellular_componentextracellular region
E0006869biological_processlipid transport
E0008289molecular_functionlipid binding
E0042157biological_processlipoprotein metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Methionine sulfoxide => ECO:0000269|PubMed:12576517
ChainResidueDetails
DMET286
DMET312
EMET586
EMET612
BGLY10
BVAL29
BALA59
BASN116

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:8261628
ChainResidueDetails
DLYS439
ELYS739

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104
BLYS104

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:29239724
ChainResidueDetails
ALYS180
BLYS180

site_idSWS_FT_FI5
Number of Residues2
DetailsLIPID: N6-palmitoyl lysine => ECO:0000269|PubMed:29239724
ChainResidueDetails
ALYS182
BLYS182

site_idSWS_FT_FI6
Number of Residues4
DetailsLIPID: N6-palmitoyl lysine => ECO:0000305|PubMed:29239724
ChainResidueDetails
ALYS184
ACYS185
BLYS184
BCYS185

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35
BTHR35

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762
ChainResidueDetails
AMET170
BMET170

226707

PDB entries from 2024-10-30

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