7RSE
NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | GTPase KRas | polymer | 185 | 21130.0 | 2 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | D, E | Apolipoprotein A-I | polymer | 200 | 23234.3 | 2 | UniProt (P02647) Pfam (PF01442) In PDB | Homo sapiens (Human) | ApoA-I,Apolipoprotein A1 |
| 3 | A, B | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 2 | Chemie (GSP) | |||
| 4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | B, D, E, A | [(2~{R})-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-2-propanoyloxy-propyl] (~{Z})-octadec-9-enoate | non-polymer | 578.7 | 128 | Chemie (7Q9) | |||
| 6 | E, B, D, A | O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine | non-polymer | 788.0 | 32 | Chemie (17F) |
Sequence modifications
A, B: 2 - 185 (UniProt: P01116)
D, E: 244 - 441 (UniProt: P02647)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 242 | - | expression tag |
| Pro 243 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88728.7 | |
| Non-Polymers* | Number of molecules | 164 |
| Total formula weight | 100423.1 | |
| All* | Total formula weight | 189151.7 |
