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2MSE

NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc

Summary for 2MSE
Entry DOI10.2210/pdb2mse/pdb
Related1AV1 2M4A 2M4B 2MSC 2MSD 3GFT 4DSN
NMR InformationBMRB: 25116
DescriptorApolipoprotein A-I, GTPase KRas, Serine/threonine-protein kinase A-Raf, ... (7 entities in total)
Functional Keywordsk-ras, nanodisc, pre, docking, a-rafrbd, lipid binding protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight139393.26
Authors
Mazhab-Jafari, M.,Stathopoulos, P.,Marshall, C.,Ikura, M. (deposition date: 2014-07-29, release date: 2015-06-03, Last modification date: 2019-12-11)
Primary citationMazhab-Jafari, M.T.,Marshall, C.B.,Smith, M.J.,Gasmi-Seabrook, G.M.,Stathopulos, P.B.,Inagaki, F.,Kay, L.E.,Neel, B.G.,Ikura, M.
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112:6625-6630, 2015
Cited by
PubMed: 25941399
DOI: 10.1073/pnas.1419895112
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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