2MSE
NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Apolipoprotein A-I | polymer | 200 | 23234.3 | 2 | UniProt (P02647) Pfam (PF01442) | Homo sapiens (Human) | ApoA-I,Apolipoprotein A1 |
| 2 | C (B) | GTPase KRas | polymer | 187 | 21260.3 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 3 | D (D) | Serine/threonine-protein kinase A-Raf | polymer | 73 | 8133.5 | 1 | UniProt (P10398) Pfam (PF02196) | Homo sapiens (Human) | Proto-oncogene A-Raf,Proto-oncogene A-Raf-1,Proto-oncogene Pks |
| 4 | AA, AB, BA, BB, CA... (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 64 | Chemie (PCW) | |||
| 5 | AC, BC, CC, DC, EC... (A) | O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine | non-polymer | 788.0 | 16 | Chemie (17F) | |||
| 6 | GC (B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 7 | HC (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A, C: 201 - 398 (UniProt: P02647)
B: 1 - 185 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
| Pro 200 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 75862.3 | |
| Non-Polymers* | Number of molecules | 82 |
| Total formula weight | 63530.9 | |
| All* | Total formula weight | 139393.3 |
