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2MSE

NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0042157biological_processlipoprotein metabolic process
B0000139cellular_componentGolgi membrane
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0001934biological_processpositive regulation of protein phosphorylation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0007165biological_processsignal transduction
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0008542biological_processvisual learning
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010467biological_processgene expression
B0010628biological_processpositive regulation of gene expression
B0012505cellular_componentendomembrane system
B0014009biological_processglial cell proliferation
B0016020cellular_componentmembrane
B0016601biological_processRac protein signal transduction
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0021897biological_processforebrain astrocyte development
B0030036biological_processactin cytoskeleton organization
B0030857biological_processnegative regulation of epithelial cell differentiation
B0032228biological_processregulation of synaptic transmission, GABAergic
B0035022biological_processpositive regulation of Rac protein signal transduction
B0035914biological_processskeletal muscle cell differentiation
B0043495molecular_functionprotein-membrane adaptor activity
B0043524biological_processnegative regulation of neuron apoptotic process
B0044877molecular_functionprotein-containing complex binding
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048873biological_processhomeostasis of number of cells within a tissue
B0051146biological_processstriated muscle cell differentiation
B0051402biological_processneuron apoptotic process
B0060252biological_processpositive regulation of glial cell proliferation
B0060441biological_processepithelial tube branching involved in lung morphogenesis
B0060509biological_processtype I pneumocyte differentiation
C0005576cellular_componentextracellular region
C0006869biological_processlipid transport
C0008289molecular_functionlipid binding
C0042157biological_processlipoprotein metabolic process
D0007165biological_processsignal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 1
ChainResidue
APCW26
APCW28
A17F35
A17F38

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PCW A 2
ChainResidue
APCW5
APCW17
APCW21
ATYR349
AHIS356

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 3
ChainResidue
APCW18
ALEU283
ALYS290

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 4
ChainResidue
APCW7
APCW16
ATYR393

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PCW A 5
ChainResidue
APCW2
APCW17
A17F36
A17F38
A17F40

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 6
ChainResidue
APCW16
APCW24
APCW28
A17F39

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 7
ChainResidue
APCW4
APCW16

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 8
ChainResidue
APCW22
APCW27
A17F37

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PCW A 9
ChainResidue
APCW11
APCW14
APCW26
APCW28
APCW29
APCW30
A17F34

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 10
ChainResidue
APCW12
APCW21
A17F36

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 11
ChainResidue
APCW9
APCW25
APCW63

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PCW A 12
ChainResidue
APCW10
APCW22
APCW30
DILE854
DLYS855
DARG857
DLYS858
DTHR859

site_idBC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 13
ChainResidue
APCW14
APCW18
APCW23
APCW27
A17F34
A17F37

site_idBC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PCW A 14
ChainResidue
APCW9
APCW13
APCW23
A17F34
A17F37
DTYR813
DLYS817

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 15
ChainResidue
APCW16
A17F39
APHE214
BLYS184

site_idBC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 16
ChainResidue
APCW4
APCW6
APCW7
APCW15
A17F39
BLYS184

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 17
ChainResidue
APCW2
APCW5
A17F36
A17F38

site_idBC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 18
ChainResidue
APCW3
APCW13
APCW27
A17F37
DGLU878
DVAL879

site_idCC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 19
ChainResidue
APCW29
BMET1
BGLU3

site_idCC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 20
ChainResidue
APCW31
BSER106
BLYS175
BLYS176
BSER181
BCYS185

site_idCC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 21
ChainResidue
APCW2
APCW10
A17F36

site_idCC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 22
ChainResidue
APCW8
APCW12
DARG857

site_idCC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 23
ChainResidue
APCW14
A17F34
DPRO815
DLYS817
DGLU878
APCW13

site_idCC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 24
ChainResidue
APCW6
APCW25
BVAL103

site_idCC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 25
ChainResidue
APCW11
APCW24
APCW29
APCW31
BGLU3
BGLU76

site_idCC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 26
ChainResidue
APCW1
APCW9
APCW28
A17F40

site_idCC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 27
ChainResidue
APCW8
APCW13
APCW18
A17F37
DTYR851
DGLU878

site_idDC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 28
ChainResidue
APCW1
APCW6
APCW9
APCW26

site_idDC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 29
ChainResidue
APCW9
APCW19
APCW25
BTHR2
BTYR4
BGLU49

site_idDC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PCW A 30
ChainResidue
APCW9
APCW12
A17F34
A17F40
DLEU853
DLYS855
DGLY856
DARG857
DILE876

site_idDC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 31
ChainResidue
APCW20
APCW25
BLYS167
BLYS175

site_idDC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 32
ChainResidue
A17F33
A17F35
A17F38

site_idDC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE 17F A 33
ChainResidue
APCW32
A17F35

site_idDC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 17F A 34
ChainResidue
APCW9
APCW13
APCW14
APCW23
APCW30
DLYS858
DILE876

site_idDC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE 17F A 35
ChainResidue
APCW1
APCW32
A17F33

site_idDC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 17F A 36
ChainResidue
APCW5
APCW10
APCW17
APCW21
A17F40
DLYS855

site_idEC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 17F A 37
ChainResidue
APCW8
APCW13
APCW14
APCW18
APCW27
DARG857
DLYS858

site_idEC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE 17F A 38
ChainResidue
APCW1
APCW5
APCW17
APCW32

site_idEC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE 17F A 39
ChainResidue
APCW6
APCW15
APCW16

site_idEC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 17F A 40
ChainResidue
APCW5
APCW26
APCW30
A17F36
DLEU853
DLYS855
DGLY856

site_idEC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PCW A 41
ChainResidue
APCW52
APCW58
APCW59
APCW60
APCW61

site_idEC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 42
ChainResidue
APCW52
APCW63
APCW69
A17F75

site_idEC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 43
ChainResidue
APCW68
APCW69
A17F75

site_idEC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 44
ChainResidue
APCW53
APCW55
A17F77

site_idEC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 45
ChainResidue
APCW47
APCW49
APCW57
A17F74

site_idFC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 46
ChainResidue
APCW71
A17F73

site_idFC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 47
ChainResidue
APCW45
A17F73
A17F76

site_idFC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 48
ChainResidue
APCW54
APCW58

site_idFC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PCW A 49
ChainResidue
APCW45
APCW57
APCW65
A17F79
A17F80

site_idFC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE PCW A 50
ChainResidue
A17F78

site_idFC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 51
ChainResidue
APCW56
APCW70
APCW71

site_idFC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PCW A 52
ChainResidue
APCW41
APCW42
APCW58
APCW60
APCW63

site_idFC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 53
ChainResidue
APCW44
APCW55
APCW64

site_idFC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 54
ChainResidue
APCW48
APCW62
APCW72

site_idGC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PCW A 55
ChainResidue
APCW44
APCW53
APCW64
A17F77
CTRP405

site_idGC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 56
ChainResidue
APCW51
APCW68
APCW70

site_idGC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 57
ChainResidue
APCW45
APCW49
A17F80

site_idGC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 58
ChainResidue
APCW41
APCW48
APCW52
APCW60

site_idGC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 59
ChainResidue
APCW41
APCW61
A17F77

site_idGC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 60
ChainResidue
APCW41
APCW52
APCW58
APCW63

site_idGC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 61
ChainResidue
APCW41
APCW59

site_idGC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 62
ChainResidue
APCW54
APCW67
APCW72
A17F78

site_idGC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PCW A 63
ChainResidue
APCW11
APCW42
APCW52
APCW60
APCW67
A17F75

site_idHC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 64
ChainResidue
APCW53
APCW55

site_idHC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 65
ChainResidue
APCW49
A17F80

site_idHC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 66
ChainResidue
APCW67
A17F78
A17F79

site_idHC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 67
ChainResidue
APCW62
APCW63
APCW66
A17F78

site_idHC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 68
ChainResidue
APCW43
APCW56
APCW69

site_idHC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 69
ChainResidue
APCW42
APCW43
APCW68

site_idHC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PCW A 70
ChainResidue
APCW51
APCW56
APCW71

site_idHC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PCW A 71
ChainResidue
APCW46
APCW51
APCW70
A17F73

site_idHC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PCW A 72
ChainResidue
APCW54
APCW62

site_idIC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE 17F A 73
ChainResidue
APCW46
APCW47
APCW71
A17F76

site_idIC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE 17F A 74
ChainResidue
APCW45
A17F75
A17F79

site_idIC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE 17F A 75
ChainResidue
APCW42
APCW43
APCW63
A17F74

site_idIC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE 17F A 76
ChainResidue
APCW47
A17F73

site_idIC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE 17F A 77
ChainResidue
APCW44
APCW55
APCW59
CTHR592

site_idIC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE 17F A 78
ChainResidue
APCW50
APCW62
APCW66
APCW67

site_idIC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE 17F A 79
ChainResidue
APCW49
APCW66
A17F74

site_idIC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE 17F A 80
ChainResidue
APCW49
APCW57
APCW65

site_idIC9
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GNP B 201
ChainResidue
BGLY12
BGLY13
BGLY15
BLYS16
BSER17
BALA18
BVAL29
BASP30
BGLU31
BTYR32
BASP33
BPRO34
BTHR35
BASN116
BALA146
BLYS147

site_idJC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 202
ChainResidue
BTHR35
BASP38
BASP57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
BGLY10
BVAL29
BALA59
BASN116

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
BMET1
CLYS594

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
BTHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
BLYS104

site_idSWS_FT_FI5
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:29239724
ChainResidueDetails
BLYS180

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: N6-palmitoyl lysine => ECO:0000269|PubMed:29239724
ChainResidueDetails
BLYS182

site_idSWS_FT_FI7
Number of Residues2
DetailsLIPID: N6-palmitoyl lysine => ECO:0000305|PubMed:29239724
ChainResidueDetails
BLYS184
BCYS185

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
BTHR35

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762
ChainResidueDetails
BMET170

218853

PDB entries from 2024-04-24

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