4O2L

Structure of Mus musculus Rheb G63A mutant bound to GTP

Summary for 4O2L

Entry DOI	10.2210/pdb4o2l/pdb
Related	4O25 4O2R
Descriptor	GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	small gtpase, hydrolase, gdp and gtp
Biological source	Mus musculus (mouse)
Cellular location	Cell membrane ; Lipid-anchor ; Cytoplasmic side : Q921J2
Total number of polymer chains	2
Total formula weight	39692.07
Authors	Mazhab-Jafari, M.T.,Marshall, C.B.,Ho, J.,Ishiyama, N.,Stambolic, V.,Ikura, M. (deposition date: 2013-12-17, release date: 2014-03-26, Last modification date: 2024-02-28)
Primary citation	Mazhab-Jafari, M.T.,Marshall, C.B.,Ho, J.,Ishiyama, N.,Stambolic, V.,Ikura, M. Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289:12195-12201, 2014 Cited by PubMed: 24648513 DOI: 10.1074/jbc.C113.543736 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation