6NBH
 
 | | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | | Deposit date: | 2018-12-07 | | Release date: | 2019-04-17 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
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5KCS
 | | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution | | Descriptor: | (2R,3R,4R,6S)-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7S,7aR)-6-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4S,5S,6S)-6-({(2R,3aS,3a'R,6S,7R,7'R,7aS,7a'S)-7'-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-7-hydroxyoctahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-4-hydroxy-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-3-hydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4',7-dihydroxy-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-4-{[(2R,4S,5R,6S)-5-methoxy-4,6-dimethyl-4-nitrotetrahydro-2H-pyran-2-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | Authors: | Arenz, S, Juette, M.F, Graf, M, Nguyen, F, Huter, P, Polikanov, Y.S, Blanchard, S.C, Wilson, D.N. | | Deposit date: | 2016-06-06 | | Release date: | 2016-08-17 | | Last modified: | 2019-12-25 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5KCR
 | | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution | | Descriptor: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | Authors: | Arenz, S, Juette, M.F, Graf, M, Nguyen, F, Huter, P, Polikanov, Y.S, Blanchard, S.C, Wilson, D.N. | | Deposit date: | 2016-06-06 | | Release date: | 2016-08-17 | | Last modified: | 2019-12-25 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3K7G
 | | Crystal structure of the Indian Hedgehog N-terminal signalling domain | | Descriptor: | GLYCEROL, Indian hedgehog protein, SULFATE ION, ... | | Authors: | He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. | | Deposit date: | 2009-10-13 | | Release date: | 2011-01-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of the Indian Hedgehog N-terminal signalling domain
To be Published
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3K7I
 | | Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain | | Descriptor: | Indian hedgehog protein, SULFATE ION, ZINC ION | | Authors: | He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. | | Deposit date: | 2009-10-13 | | Release date: | 2011-01-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.438 Å) | | Cite: | Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain
To be Published
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3K7H
 | | Crystal structure of the E95K mutant of the Indian Hedgehog N-terminal signalling domain | | Descriptor: | Indian hedgehog protein, SULFATE ION, ZINC ION | | Authors: | He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. | | Deposit date: | 2009-10-13 | | Release date: | 2011-01-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of the E95K mutant of the Indian Hedgehog N-terminal signalling domain
To be Published
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3K7J
 | | Crystal structure of the D100E mutant of the Indian Hedgehog N-terminal signalling domain | | Descriptor: | CARBONATE ION, Indian hedgehog protein, SULFATE ION, ... | | Authors: | He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. | | Deposit date: | 2009-10-13 | | Release date: | 2011-01-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the D100E mutant of the Indian Hedgehog N-terminal signalling domain
To be Published
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6JPF
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6JB3
 | | Structure of SUR1 subunit bound with repaglinide | | Descriptor: | ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide | | Authors: | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | | Deposit date: | 2019-01-25 | | Release date: | 2019-05-22 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
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3PUB
 | | Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7) | | Descriptor: | 30kDa protein | | Authors: | Yang, J.-P, Ma, X.-X, He, Y.-X, Li, W.-F, Kang, Y, Bao, R, Chen, Y, Zhou, C.-Z. | | Deposit date: | 2010-12-03 | | Release date: | 2011-06-01 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Crystal structure of the 30 K protein from the silkworm Bombyx mori reveals a new member of the beta-trefoil superfamily
J.Struct.Biol., 175, 2011
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4QMG
 | | The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions | | Descriptor: | CESIUM ION, GLYCEROL, Protein LYRIC, ... | | Authors: | Guo, F, Stanevich, V, Wan, L, Satyshur, K, Kang, Y, Xing, Y. | | Deposit date: | 2014-06-16 | | Release date: | 2014-10-08 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex.
Cell Rep, 8, 2014
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5VP2
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution | | Descriptor: | 16S ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Osterman, I.A, Khabibullina, N.F, Komarova, E.S, Kasatsky, P, Kartsev, V.G, Bogdanov, A.A, Dontsova, O.A, Konevega, A.L, Sergiev, P.V, Polikanov, Y.S. | | Deposit date: | 2017-05-04 | | Release date: | 2017-06-28 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res., 45, 2017
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3B2C
 | | Crystal structure of the collagen triple helix model [{PRO-HYP(R)-GLY}4-{HYP(S)-Pro-GLY}2-{PRO-HYP(R)-GLY}4]3 | | Descriptor: | Collagen-like peptide | | Authors: | Motooka, D, Kawahara, K, Nakamura, S, Doi, M, Nishi, Y, Nishiuchi, Y, Nakazawa, T, Yoshida, T, Ohkubo, T, Kobayashi, Y, Kang, Y.K, Uchiyama, S. | | Deposit date: | 2011-07-26 | | Release date: | 2012-04-04 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | The triple helical structure and stability of collagen model peptide with 4(S)-hydroxyprolyl-pro-gly units
Biopolymers, 98, 2011
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6CAE
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Pantel, L, Florin, T, Dobosz-Bartoszek, M, Racine, E, Sarciaux, M, Serri, M, Houard, J, Campagne, J.M, Marcia de Figueiredo, R, Midrier, C, Gaudriault, S, Givaudan, A, Lanois, A, Forst, S, Aumelas, A, Cotteaux-Lautard, C, Bolla, J.M, Vingsbo Lundberg, C, Huseby, D, Hughes, D, Villain-Guillot, P, Mankin, A.S, Polikanov, Y.S, Gualtieri, M. | | Deposit date: | 2018-01-30 | | Release date: | 2018-04-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Mol. Cell, 70, 2018
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3AP1
 | | Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4 peptide | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, C4 peptide, GLYCEROL, ... | | Authors: | Teramoto, T, Fujikawa, Y, Kawaguchi, Y, Kurogi, K, Soejima, M, Adachi, R, Nakanishi, Y, Mishiro-Sato, E, Liu, M.-C, Sakakibara, Y, Suiko, M, Kimura, M, Kakuta, Y. | | Deposit date: | 2010-10-09 | | Release date: | 2011-10-26 | | Last modified: | 2013-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.
Nat Commun, 4, 2013
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6CFJ
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Tereshchenkov, A.G, Dobosz-Bartoszek, M, Osterman, I.A, Marks, J, Sergeeva, V.A, Kasatsky, P, Komarova, E.S, Stavrianidi, A.N, Rodin, I.A, Konevega, A.L, Sergiev, P.V, Sumbatyan, N.V, Mankin, A.S, Bogdanov, A.A, Polikanov, Y.S. | | Deposit date: | 2018-02-15 | | Release date: | 2018-03-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
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3AP2
 | | Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP,C4 peptide, and phosphate ion | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, C4 peptide, GLYCEROL, ... | | Authors: | Teramoto, T, Fujikawa, Y, Kawaguchi, Y, Kurogi, K, Soejima, M, Adachi, R, Nakanishi, Y, Mishiro-Sato, E, Liu, M.-C, Sakakibara, Y, Suiko, M, Kimura, M, Kakuta, Y. | | Deposit date: | 2010-10-09 | | Release date: | 2011-10-26 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of human tyrosylprotein sulfotransferase-2: Insights into substrate-binding and catalysis of post-translational protein tyrosine sulfation
To be Published
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3AP3
 | | Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Protein-tyrosine sulfotransferase 2 | | Authors: | Teramoto, T, Fujikawa, Y, Kawaguchi, Y, Kurogi, K, Soejima, M, Adachi, R, Nakanishi, Y, Mishiro-Sato, E, Liu, M.-C, Sakakibara, Y, Suiko, M, Kimura, M, Kakuta, Y. | | Deposit date: | 2010-10-09 | | Release date: | 2011-10-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.
Nat Commun, 4, 2013
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3WAQ
 | | Hemerythrin-like domain of DcrH I119E mutant (met) | | Descriptor: | Hemerythrin-like domain protein DcrH, MU-OXO-DIIRON | | Authors: | Okamoto, Y, Onoda, A, Sugimoto, H, Takano, Y, Hirota, S, Kurtz Jr, D.M, Shiro, Y, Hayashi, T. | | Deposit date: | 2013-05-07 | | Release date: | 2014-03-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure, exogenous ligand binding, and redox properties of an engineered diiron active site in a bacterial hemerythrin
Inorg.Chem., 52, 2013
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8J1N
 | | Structure of human UCP1 in the DNP-bound state | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ... | | Authors: | Chen, L, Kang, Y. | | Deposit date: | 2023-04-13 | | Release date: | 2023-06-21 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.51 Å) | | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
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7D9R
 | | Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9U
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9S
 | | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9T
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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6N9E
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S19, ... | | Authors: | Melnikov, S.V, Khabibullina, N.F, Mairhofer, E, Vargas-Rodriguez, O, Reynolds, N.M, Micura, R, Soll, D, Polikanov, Y.S. | | Deposit date: | 2018-12-03 | | Release date: | 2018-12-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
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