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6CAE

Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution

This is a non-PDB format compatible entry.
Summary for 6CAE
Entry DOI10.2210/pdb6cae/pdb
Descriptor23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
Functional Keywordsnoso-95179, odilorhabdin, antibiotic, inhibitor, ribosome, 70s, ribosome structure, inhibition of translation, decoding center, ribosome-inhibitor complex, ribosome/inhibitor
Biological sourceEscherichia coli
More
Total number of polymer chains115
Total formula weight4576003.21
Authors
Primary citationPantel, L.,Florin, T.,Dobosz-Bartoszek, M.,Racine, E.,Sarciaux, M.,Serri, M.,Houard, J.,Campagne, J.M.,de Figueiredo, R.M.,Midrier, C.,Gaudriault, S.,Givaudan, A.,Lanois, A.,Forst, S.,Aumelas, A.,Cotteaux-Lautard, C.,Bolla, J.M.,Vingsbo Lundberg, C.,Huseby, D.L.,Hughes, D.,Villain-Guillot, P.,Mankin, A.S.,Polikanov, Y.S.,Gualtieri, M.
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Mol. Cell, 70:83-94.e7, 2018
Cited by
PubMed: 29625040
DOI: 10.1016/j.molcel.2018.03.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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