7D9R

Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state

Summary for 7D9R

• Entry DOI: 10.2210/pdb7d9r/pdb
• EMDB information: 30618
• Descriptor: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: soluble guanylate cyclase, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 149774.52

Authors

Chen, L.,Liu, R.,Kang, Y. (deposition date: 2020-10-14, release date: 2021-08-11, Last modification date: 2021-10-13)

• Primary citation: Liu, R.,Kang, Y.,Chen, L.; Activation mechanism of human soluble guanylate cyclase by stimulators and activators.; Nat Commun, 12:5492-5492, 2021; PubMed: 34535643; DOI: 10.1038/s41467-021-25617-0

Experimental method

ELECTRON MICROSCOPY (3.3 Å)