7D9T
Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state
Summary for 7D9T
Entry DOI | 10.2210/pdb7d9t/pdb |
EMDB information | 30620 |
Descriptor | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid (3 entities in total) |
Functional Keywords | soluble guanylate cyclase, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 148731.50 |
Authors | |
Primary citation | Liu, R.,Kang, Y.,Chen, L. Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12:5492-5492, 2021 Cited by PubMed: 34535643DOI: 10.1038/s41467-021-25617-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.1 Å) |
Structure validation
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