7D9T
Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanylate cyclase soluble subunit alpha-1 | polymer | 690 | 77566.5 | 1 | UniProt (Q02108) Pfam (PF07701) Pfam (PF00211) | Homo sapiens (Human) | GCS-alpha-1,Guanylate cyclase soluble subunit alpha-3,GCS-alpha-3,Soluble guanylate cyclase large subunit |
| 2 | B (B) | Guanylate cyclase soluble subunit beta-1 | polymer | 619 | 70599.3 | 1 | UniProt (Q02153) Pfam (PF07700) Pfam (PF07701) Pfam (PF00211) | Homo sapiens (Human) | GCS-beta-1,Guanylate cyclase soluble subunit beta-3,GCS-beta-3,Soluble guanylate cyclase small subunit |
| 3 | C (B) | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid | non-polymer | 565.7 | 1 | Chemie (Z90) |
Sequence modifications
A: 1 - 690 (UniProt: Q02108)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | Val 44 | variant |
| Val 554 | Leu 554 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 148165.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 565.7 | |
| All* | Total formula weight | 148731.5 |
