7D57
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![BU of 7d57 by Molmil](/molmil-images/mine/7d57) | C-Src in complex with FIIN-2 | Descriptor: | N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION | Authors: | Chen, Y.H, Qu, L.Z. | Deposit date: | 2020-09-25 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors Commun Chem, 5, 2022
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8GVJ
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![BU of 8gvj by Molmil](/molmil-images/mine/8gvj) | Crystal structure of cMET kinase domain bound by D6808 | Descriptor: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | Authors: | Chen, Y.H, Qu, L.Z. | Deposit date: | 2022-09-15 | Release date: | 2022-11-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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7XPQ
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![BU of 7xpq by Molmil](/molmil-images/mine/7xpq) | |
7XPO
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![BU of 7xpo by Molmil](/molmil-images/mine/7xpo) | Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD/UDP-Glc | Descriptor: | GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase, ... | Authors: | Chen, Y.H, Wang, X.C, Zhang, C.R. | Deposit date: | 2022-05-05 | Release date: | 2023-05-17 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis. Nat Commun, 14, 2023
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7XPP
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5Y26
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![BU of 5y26 by Molmil](/molmil-images/mine/5y26) | Crystal structure of native Dpb4-Dpb3 | Descriptor: | DNA polymerase epsilon subunit D, GLYCEROL, Putative transcription factor C16C4.22 | Authors: | Chen, Y.H, Li, Y, Gao, F. | Deposit date: | 2017-07-24 | Release date: | 2018-01-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6LBI
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7D5O
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![BU of 7d5o by Molmil](/molmil-images/mine/7d5o) | C-Src in complex with TAS-120 | Descriptor: | 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one, Proto-oncogene tyrosine-protein kinase Src | Authors: | Qu, L.Z, Chen, Y.H. | Deposit date: | 2020-09-27 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors Commun Chem, 5, 2022
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8XLO
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8Y22
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![BU of 8y22 by Molmil](/molmil-images/mine/8y22) | FGFR1 kinase domain with a covalent inhibitor 9g | Descriptor: | Fibroblast growth factor receptor 1, SULFATE ION, ~{N}-[4-[[4-azanyl-3-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]propanamide | Authors: | Chen, X.J, Chen, Y.H. | Deposit date: | 2024-01-25 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.792 Å) | Cite: | Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors. Eur.J.Med.Chem., 275, 2024
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8XZ7
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![BU of 8xz7 by Molmil](/molmil-images/mine/8xz7) | FGFR1 kinase domain with a covalent inhibitor 10h | Descriptor: | 5-azanyl-3-[2-[4,6-bis(fluoranyl)-2-methyl-3~{H}-benzimidazol-5-yl]ethynyl]-1-[[3-(prop-2-enoylamino)phenyl]methyl]pyrazole-4-carboxamide, Fibroblast growth factor receptor 1, SULFATE ION | Authors: | Chen, X.J, Chen, Y.H. | Deposit date: | 2024-01-20 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors. Eur.J.Med.Chem., 275, 2024
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8XLQ
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7V29
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![BU of 7v29 by Molmil](/molmil-images/mine/7v29) | Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor | Descriptor: | Fibroblast growth factor receptor 4, N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide, SULFATE ION | Authors: | Chen, X.J, Jiang, L.Y, Dai, S.Y, Qu, L.Z, Chen, Y.H. | Deposit date: | 2021-08-07 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.983 Å) | Cite: | Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem, 5, 2022
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4Q9V
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![BU of 4q9v by Molmil](/molmil-images/mine/4q9v) | Crystal structure of TIPE3 | Descriptor: | CHLORIDE ION, SULFATE ION, Tumor necrosis factor alpha-induced protein 8-like protein 3 | Authors: | Wu, J, Zhang, X, Chen, Y.H, Shi, Y. | Deposit date: | 2014-05-02 | Release date: | 2014-10-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer. Cancer Cell, 26, 2014
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7CBY
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![BU of 7cby by Molmil](/molmil-images/mine/7cby) | Structure of FOXG1 DNA binding domain bound to DBE2 DNA site | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), ... | Authors: | Dai, S.Y, Li, J, Chen, Y.H. | Deposit date: | 2020-06-15 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.646 Å) | Cite: | Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J.Mol.Biol., 432, 2020
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8HF2
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![BU of 8hf2 by Molmil](/molmil-images/mine/8hf2) | Cryo-EM structure of WeiTsing | Descriptor: | PRA1 family protein | Authors: | Qin, L, Tang, L.H, Chen, Y.H. | Deposit date: | 2022-11-09 | Release date: | 2023-06-21 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance. Cell, 186, 2023
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8JMZ
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![BU of 8jmz by Molmil](/molmil-images/mine/8jmz) | FGFR1 kinase domain with sulfatinib | Descriptor: | Fibroblast growth factor receptor 1, GLYCEROL, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide, ... | Authors: | Chen, X.J, Lin, Q.M, Chen, Y.H. | Deposit date: | 2023-06-05 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.988 Å) | Cite: | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R. Commun Chem, 7, 2024
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8JOT
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![BU of 8jot by Molmil](/molmil-images/mine/8jot) | Crystal structure of CSF-1R kinase domain with sulfatinib | Descriptor: | GLYCEROL, Macrophage colony-stimulating factor 1 receptor, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide | Authors: | Lin, Q.M, Chen, X.J, Chen, Y.H. | Deposit date: | 2023-06-08 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R. Commun Chem, 7, 2024
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7W6K
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![BU of 7w6k by Molmil](/molmil-images/mine/7w6k) | Cryo-EM structure of GmALMT12/QUAC1 anion channel | Descriptor: | GmALMT12/QUAC1 | Authors: | Qin, L, Tang, L.H, Xu, J.S, Zhang, X.H, Zhu, Y, Sun, F, Su, M, Zhai, Y.J, Chen, Y.H. | Deposit date: | 2021-12-01 | Release date: | 2022-03-16 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a previously uncharacterized class of anion channels. Sci Adv, 8, 2022
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7XGT
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6IZ4
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![BU of 6iz4 by Molmil](/molmil-images/mine/6iz4) | Crystal Structure Analysis of TRIC counter-ion channels in calcium release | Descriptor: | Trimeric intracellular cation channel type B-B | Authors: | Wang, X.H, Zeng, Y, Gao, F, Su, M, Hendrickson, W.A, Chen, Y.H. | Deposit date: | 2018-12-18 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.098 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6IYU
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![BU of 6iyu by Molmil](/molmil-images/mine/6iyu) | Crystal Structure Analysis of an Eukaryotic Membrane Protein | Descriptor: | CALCIUM ION, CHLORIDE ION, Trimeric intracellular cation channel type A | Authors: | Wang, X.H, Zeng, Y, Su, M, Gao, F, Chen, Y.H. | Deposit date: | 2018-12-17 | Release date: | 2019-05-01 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6IZ1
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![BU of 6iz1 by Molmil](/molmil-images/mine/6iz1) | Crystal Structure Analysis of a Eukaryotic Membrane Protein | Descriptor: | CALCIUM ION, CHLORIDE ION, Trimeric intracellular cation channel type A | Authors: | Wang, X.H, Zeng, Y, Gao, F, Su, M, Chen, Y.H. | Deposit date: | 2018-12-18 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6IZ0
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![BU of 6iz0 by Molmil](/molmil-images/mine/6iz0) | Crystal Structure Analysis of a Eukaryotic Membrane Protein | Descriptor: | CALCIUM ION, CHLORIDE ION, Trimeric intracellular cation channel type A | Authors: | Wang, X.H, Zeng, Y, Gao, F, Su, M, Chen, Y.H. | Deposit date: | 2018-12-18 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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6IYX
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![BU of 6iyx by Molmil](/molmil-images/mine/6iyx) | Crystal Structure Analysis of a Eukaryotic Membrane Protein | Descriptor: | BROMIDE ION, CALCIUM ION, Trimeric intracellular cation channel type A | Authors: | Zeng, Y, Wang, X.H, Gao, F, Su, M, Chen, Y.H. | Deposit date: | 2018-12-17 | Release date: | 2019-05-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for activity of TRIC counter-ion channels in calcium release. Proc.Natl.Acad.Sci.USA, 116, 2019
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