7V29

Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor

Summary for 7V29

• Entry DOI: 10.2210/pdb7v29/pdb
• Descriptor: Fibroblast growth factor receptor 4, N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, dual-warhead, fibroblast growth factor receptor 4, covalent, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71131.91

Authors

Chen, X.J.,Jiang, L.Y.,Dai, S.Y.,Qu, L.Z.,Chen, Y.H. (deposition date: 2021-08-07, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Chen, X.,Li, H.,Lin, Q.,Dai, S.,Yue, S.,Qu, L.,Li, M.,Guo, M.,Wei, H.,Li, J.,Jiang, L.,Xu, G.,Chen, Y.; Structure-based design of a dual-warhead covalent inhibitor of FGFR4.; Commun Chem, 5:36-36, 2022; PubMed: 36697897; DOI: 10.1038/s42004-022-00657-9

Experimental method

X-RAY DIFFRACTION (1.983 Å)