7V29
Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Fibroblast growth factor receptor 4 | polymer | 311 | 34695.1 | 2 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (Human) | FGFR-4 |
| 2 | C, G (B, A) | N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide | non-polymer | 630.7 | 2 | Chemie (5JR) | |||
| 3 | D, E, F, H, I (B, A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | J, K (B, A) | water | water | 18.0 | 421 | Chemie (HOH) |
Sequence modifications
B, A: 445 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | expression tag |
| Pro 444 | - | expression tag |
| Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69390.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1741.8 | |
| All* | Total formula weight | 71131.9 |
