8JOT

Crystal structure of CSF-1R kinase domain with sulfatinib

Summary for 8JOT

• Entry DOI: 10.2210/pdb8jot/pdb
• Descriptor: Macrophage colony-stimulating factor 1 receptor, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: sulfatinib, fgfr1, dfg-out, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40513.33

Authors

Lin, Q.M.,Chen, X.J.,Chen, Y.H. (deposition date: 2023-06-08, release date: 2024-03-27)

• Primary citation: Lin, Q.,Dai, S.,Qu, L.,Lin, H.,Guo, M.,Wei, H.,Chen, Y.,Chen, X.; Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.; Commun Chem, 7:3-3, 2024; PubMed: 38172256; DOI: 10.1038/s42004-023-01084-0

Experimental method

X-RAY DIFFRACTION (1.69 Å)