8JOT

Crystal structure of CSF-1R kinase domain with sulfatinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Macrophage colony-stimulating factor 1 receptor	polymer	354	39940.7	1	UniProt (P07333) Pfam (PF07714)	Homo sapiens (human)	CSF-1 receptor,CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms
2	B (A)	Sulfatinib	non-polymer		480.6	1	Chemie (UKI)
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (A)	water	water		18.0	312	Chemie (HOH)

Sequence modifications

A: 542 - 919 (UniProt: P07333)

PDB	External Database	Details
Met 531	-	initiating methionine
Lys 532	-	expression tag
Lys 533	-	expression tag
Gly 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
Gly 541	-	expression tag
Thr 667	Cys 667	engineered mutation
-	Lys 707	deletion
-	Tyr 708	deletion
-	Val 709	deletion
-	Arg 710	deletion
-	Arg 711	deletion
-	Asp 712	deletion
-	Ser 713	deletion
-	Gly 714	deletion
-	Phe 715	deletion
-	Ser 716	deletion
-	Ser 717	deletion
-	Gln 718	deletion
-	Gly 719	deletion
-	Val 720	deletion
-	Asp 721	deletion
-	Thr 722	deletion
-	Tyr 723	deletion
-	Val 724	deletion
-	Glu 725	deletion
-	Met 726	deletion
-	Arg 727	deletion
-	Pro 728	deletion
-	Val 729	deletion
-	Ser 730	deletion
-	Thr 731	deletion
-	Ser 732	deletion
-	Ser 733	deletion
-	Asn 734	deletion
-	Asp 735	deletion
-	Ser 736	deletion
-	Phe 737	deletion
-	Ser 738	deletion
-	Glu 739	deletion
-	Gln 740	deletion
-	Asp 741	deletion
Ser 830	Cys 830	engineered mutation
Thr 907	Cys 907	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	39940.7
Non-Polymers*	Number of molecules	2
	Total formula weight	572.7
All*	Total formula weight	40513.3

*Water molecules are not included.