8XZ7

FGFR1 kinase domain with a covalent inhibitor 10h

This is a non-PDB format compatible entry.

Summary for 8XZ7

• Entry DOI: 10.2210/pdb8xz7/pdb
• Descriptor: Fibroblast growth factor receptor 1, SULFATE ION, 5-azanyl-3-[2-[4,6-bis(fluoranyl)-2-methyl-3~{H}-benzimidazol-5-yl]ethynyl]-1-[[3-(prop-2-enoylamino)phenyl]methyl]pyrazole-4-carboxamide, ... (4 entities in total)
• Functional Keywords: fibroblast growth factor receptor 1, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 71960.25

Authors

Chen, X.J.,Chen, Y.H. (deposition date: 2024-01-20, release date: 2024-06-26)

• Primary citation: Deng, W.,Chen, X.,Liang, H.,Song, X.,Xiang, S.,Guo, J.,Tu, Z.,Zhou, Y.,Chen, Y.,Lu, X.; Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.; Eur.J.Med.Chem., 275:116558-116558, 2024; PubMed: 38870833; DOI: 10.1016/j.ejmech.2024.116558

Experimental method

X-RAY DIFFRACTION (1.75 Å)