8XZ7

FGFR1 kinase domain with a covalent inhibitor 10h

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Fibroblast growth factor receptor 1	polymer	310	35264.5	2	UniProt (P11362) Pfam (PF07714)	Homo sapiens (human)	FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2	C, D, E, G, H (B, A)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	F, I (B, A)	5-azanyl-3-[2-[4,6-bis(fluoranyl)-2-methyl-3~{H}-benzimidazol-5-yl]ethynyl]-1-[[3-(prop-2-enoylamino)phenyl]methyl]pyrazole-4-carboxamide	non-polymer		475.4	2	Chemie (A1LWW)
4	J, K (B, A)	water	water		18.0	362	Chemie (HOH)

Sequence modifications

B, A: 458 - 765 (UniProt: P11362)

PDB	External Database	Details
Gly 456	-	expression tag
Pro 457	-	expression tag
Ser 584	Cys 584	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70529.0
Non-Polymers*	Number of molecules	7
	Total formula weight	1431.2
All*	Total formula weight	71960.3

*Water molecules are not included.