7D57

C-Src in complex with FIIN-2

Summary for 7D57

• Entry DOI: 10.2210/pdb7d57/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase inhibitor, transferase
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66918.90

Authors

Chen, Y.H.,Qu, L.Z. (deposition date: 2020-09-25, release date: 2021-10-13, Last modification date: 2023-11-29)

• Primary citation: Qu, L.,Chen, X.,Wei, H.,Guo, M.,Dai, S.,Jiang, L.,Li, J.,Yue, S.,Chen, Z.,Chen, Y.; Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors; Commun Chem, 5:5-, 2022; DOI: 10.1038/s42004-021-00623-x

Experimental method

X-RAY DIFFRACTION (2.104 Å)