8XLO

FGFR1 kinase domain with a dual-warhead covalent inhibitor CXF-007

This is a non-PDB format compatible entry.

Summary for 8XLO

• Entry DOI: 10.2210/pdb8xlo/pdb
• Descriptor: Fibroblast growth factor receptor 1, CXF007, SULFATE ION, ... (4 entities in total)
• Functional Keywords: fibroblast growth factor receptor 1, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 72344.76

Authors

Chen, X.J.,Chen, Y.H. (deposition date: 2023-12-26, release date: 2024-03-27)

• Primary citation: Chen, X.,Li, H.,Lin, Q.,Dai, S.,Qu, L.,Guo, M.,Zhang, L.,Liao, J.,Wei, H.,Xu, G.,Jiang, L.,Chen, Y.; Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.; Eur.J.Med.Chem., 268:116281-116281, 2024; PubMed: 38432058; DOI: 10.1016/j.ejmech.2024.116281

Experimental method

X-RAY DIFFRACTION (2.36 Å)