8XLO
FGFR1 kinase domain with a dual-warhead covalent inhibitor CXF-007
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Fibroblast growth factor receptor 1 | polymer | 310 | 35264.5 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | A, B | CXF007 | non-polymer | 619.7 | 2 | Chemie (A1LVQ) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 456 | - | expression tag |
| Pro 457 | - | expression tag |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70529.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1815.7 | |
| All* | Total formula weight | 72344.8 |
