8GVJ

Crystal structure of cMET kinase domain bound by D6808

Summary for 8GVJ

Entry DOI	10.2210/pdb8gvj/pdb
Descriptor	Hepatocyte growth factor receptor, (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione (3 entities in total)
Functional Keywords	inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35400.87
Authors	Chen, Y.H.,Qu, L.Z. (deposition date: 2022-09-15, release date: 2022-11-23, Last modification date: 2023-11-29)
Primary citation	Wang, C.,Li, J.,Qu, L.,Tang, X.,Song, X.,Yang, F.,Chen, X.,Lin, Q.,Lin, W.,Zhou, Y.,Tu, Z.,Chen, Y.,Zhang, Z.,Lu, X. Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65:15140-15164, 2022 Cited by PubMed: 36355693 DOI: 10.1021/acs.jmedchem.2c00981 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation