7D5O

C-Src in complex with TAS-120

Summary for 7D5O

• Entry DOI: 10.2210/pdb7d5o/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one (3 entities in total)
• Functional Keywords: transferase inhibitor, transferase
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 2
• Total formula weight: 66290.19

Authors

Qu, L.Z.,Chen, Y.H. (deposition date: 2020-09-27, release date: 2021-12-22, Last modification date: 2023-11-29)

• Primary citation: Qu, L.,Chen, X.,Wei, H.,Guo, M.,Dai, S.,Jiang, L.,Li, J.,Yue, S.,Chen, Z.,Chen, Y.; Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors; Commun Chem, 5:5-, 2022; DOI: 10.1038/s42004-021-00623-x

Experimental method

X-RAY DIFFRACTION (2.69 Å)