6PZT
| cryo-EM structure of human NKCC1 | Descriptor: | Solute carrier family 12 member 2 | Authors: | Cao, E, Wang, Q, Yang, X. | Deposit date: | 2019-08-01 | Release date: | 2020-03-25 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy. Nat Commun, 11, 2020
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6WB8
| Cryo-EM structure of PKD2 C331S disease variant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Cao, E, Wang, J, Decaen, P.G. | Deposit date: | 2020-03-26 | Release date: | 2020-04-22 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain. Proc.Natl.Acad.Sci.USA, 117, 2020
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2IF7
| Crystal Structure of NTB-A | Descriptor: | CALCIUM ION, CHLORIDE ION, SLAM family member 6 | Authors: | Cao, E, Ramagopal, U.A, Fedorov, A.A, Fedorov, E.V, Nathenson, S.G, Almo, S.C. | Deposit date: | 2006-09-20 | Release date: | 2006-10-17 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family. Immunity, 25, 2006
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2OYP
| T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface | Descriptor: | Hepatitis A virus cellular receptor 2, SULFATE ION | Authors: | Cao, E, Ramagopal, U.A, Fedorov, A.A, Fedorov, E.V, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-02-22 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface Immunity, 26, 2007
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9BWT
| human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide | Descriptor: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | Authors: | Cao, E.H, Zhao, Y.X. | Deposit date: | 2024-05-21 | Release date: | 2024-09-04 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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7S1Y
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7S1X
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7S1Z
| Cryo-EM structure of Human NKCC1 K289NA492EL671C | Descriptor: | Solute carrier family 12 member 2 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2021-09-02 | Release date: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13, 2022
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7TTI
| Human KCC1 bound with VU0463271 In an outward-open state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2022-02-01 | Release date: | 2022-06-29 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TTH
| Human potassium-chloride cotransporter 1 in inward-open state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2022-02-01 | Release date: | 2022-06-29 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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1NPU
| CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1 | Descriptor: | Programmed cell death protein 1 | Authors: | Zhang, X, Schwartz, J.-C.D, Guo, X, Cao, E, Chen, L, Zhang, Z.-Y, Nathenson, S.G, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-01-20 | Release date: | 2004-03-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity, 20, 2004
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6D1W
| human PKD2 F604P mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E. | Deposit date: | 2018-04-12 | Release date: | 2018-06-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun, 9, 2018
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3J5Q
| Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy | Descriptor: | Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 | Authors: | Liao, M, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2013-10-28 | Release date: | 2013-12-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | TRPV1 structures in distinct conformations reveal activation mechanisms. Nature, 504, 2013
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3J5R
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3J5P
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5T4D
| Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2 | Authors: | Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E. | Deposit date: | 2016-08-29 | Release date: | 2016-11-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell, 167, 2016
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5IRX
| Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc | Descriptor: | (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2016-03-14 | Release date: | 2016-05-25 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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5IS0
| Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc | Descriptor: | Transient receptor potential cation channel subfamily V member 1, capsazepine | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2016-03-15 | Release date: | 2016-05-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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3BP5
| Crystal structure of the mouse PD-1 and PD-L2 complex | Descriptor: | GLYCEROL, Programmed cell death 1 ligand 2, Programmed cell death protein 1 | Authors: | Yan, Q, Lazar-Molnar, E, Cao, E, Ramagopal, U.A, Toro, R, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-12-18 | Release date: | 2008-07-15 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3BP6
| Crystal structure of the mouse PD-1 Mutant and PD-L2 complex | Descriptor: | GLYCEROL, Programmed cell death 1 ligand 2, Programmed cell death protein 1 | Authors: | Yan, Q, Lazar-Molnar, E, Cao, E, Ramagopal, U.A, Toro, R, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-12-18 | Release date: | 2009-02-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of the mouse PD-1 A99L and PD-L2 complex To be published
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5IRZ
| Structure of TRPV1 determined in lipid nanodisc | Descriptor: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2016-03-15 | Release date: | 2016-05-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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3BOV
| Crystal structure of the receptor binding domain of mouse PD-L2 | Descriptor: | FORMIC ACID, Programmed cell death 1 ligand 2, SODIUM ION | Authors: | Lazar-Molnar, E, Ramagopal, U, Cao, E, Toro, R, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-12-17 | Release date: | 2008-07-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proc.Natl.Acad.Sci.USA, 105, 2008
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2PKD
| Crystal structure of CD84: Insite into SLAM family function | Descriptor: | CHLORIDE ION, SLAM family member 5 | Authors: | Yan, Q, Malashkevich, V.N, Fedorov, A, Cao, E, Lary, J.W, Cole, J.L, Nathenson, S.G, Almo, S.C. | Deposit date: | 2007-04-17 | Release date: | 2007-06-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.043 Å) | Cite: | Structure of CD84 provides insight into SLAM family function. Proc.Natl.Acad.Sci.Usa, 104, 2007
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8VPN
| Phosphorylated human NCC in complex with indapamide | Descriptor: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2024-01-16 | Release date: | 2024-09-04 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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8VPP
| Phosphorylated human NCC in complex with chlorthalidone | Descriptor: | 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Solute carrier family 12 member 3 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2024-01-16 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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