2IF7
Crystal Structure of NTB-A
Summary for 2IF7
| Entry DOI | 10.2210/pdb2if7/pdb |
| Descriptor | SLAM family member 6, CALCIUM ION, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | ntb-a, slam6, ly108, homophilic receptor, immune system |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane ; Single-pass type I membrane protein : Q96DU3 |
| Total number of polymer chains | 4 |
| Total formula weight | 86857.20 |
| Authors | Cao, E.,Ramagopal, U.A.,Fedorov, A.A.,Fedorov, E.V.,Nathenson, S.G.,Almo, S.C. (deposition date: 2006-09-20, release date: 2006-10-17, Last modification date: 2024-11-06) |
| Primary citation | Cao, E.,Ramagopal, U.A.,Fedorov, A.,Fedorov, E.,Yan, Q.,Lary, J.W.,Cole, J.L.,Nathenson, S.G.,Almo, S.C. NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family. Immunity, 25:559-570, 2006 Cited by PubMed Abstract: The signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and adaptive immunity. The ectodomains of most SLAM family members are composed of an N-terminal IgV domain and a C-terminal IgC2 domain. NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities but differ in detailed organization and physicochemical properties of their respective interfaces. The NTB-A structure suggests a mechanism responsible for binding specificity within the SLAM family and imposes physical constraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in the immunological synapse. PubMed: 17045824DOI: 10.1016/j.immuni.2006.06.020 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report
