7S1X
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Summary for 7S1X
Entry DOI | 10.2210/pdb7s1x/pdb |
EMDB information | 24807 24812 24813 |
Descriptor | Solute carrier family 12 member 2, 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | cation-chloride cotransporter, ion transport, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 264655.22 |
Authors | |
Primary citation | Zhao, Y.,Roy, K.,Vidossich, P.,Cancedda, L.,De Vivo, M.,Forbush, B.,Cao, E. Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide Nat Commun, 13:2747-, 2022 Cited by DOI: 10.1038/s41467-022-30407-3PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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