5IRX

Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc

Summary for 5IRX

Related5IRZ 5IS0
EMDB information8117 8118 8119 8120 5776
DescriptorTransient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... (6 entities in total)
Functional Keywordstrp, ion channel, nanodisc, vanilloid, lipid, transport protein
Biological sourceRattus norvegicus (Rat)
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Cellular locationCell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein  O35433
Secreted P0CH43
Total number of polymer chains6
Total molecular weight317876.56
Authors
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2016-03-14, release date: 2016-05-25, Last modification date: 2017-09-13)
Primary citation
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y.
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534:347-351, 2016
PubMed: 27281200 (PDB entries with the same primary citation)
DOI: 10.1038/nature17964
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (2.95 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers60.1%0MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

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