Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc

Summary for 5IRX

Related5IRZ 5IS0
EMDB information8117 8118 8119 8120 5776
DescriptorTransient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... (6 entities in total)
Functional Keywordstrp, ion channel, nanodisc, vanilloid, lipid, transport protein
Biological sourceRattus norvegicus (Rat)
Cellular locationCell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein  O35433
Secreted P0CH43
Total number of polymer chains6
Total molecular weight317876.56
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2016-03-14, release date: 2016-05-25, Last modification date: 2017-09-13)
Primary citation
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y.
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534:347-351, 2016
PubMed: 27281200 (PDB entries with the same primary citation)
DOI: 10.1038/nature17964
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers60.1%0MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

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