Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IRX

Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0008289	molecular_function	lipid binding
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
E	0099106	molecular_function	ion channel regulator activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0008289	molecular_function	lipid binding
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 6O8 A 801

Chain	Residue
A	ASN437
A	VAL440
A	TYR487
A	PHE488
A	ARG491
A	GLU513
A	PHE516
A	TYR554
A	TYR555

site_id	AC2
Number of Residues	5
Details	binding site for residue 6OE A 802

Chain	Residue
A	SER629
A	TYR631
C	TYR453
F	ALA66
F	PHE67

site_id	AC3
Number of Residues	3
Details	binding site for residue 6OE A 803

Chain	Residue
A	SER532
A	ARG534
F	6O9102

site_id	AC4
Number of Residues	17
Details	binding site for residue 6EU A 804

Chain	Residue
A	TYR511
A	SER512
A	ILE514
A	LEU515
A	ALA546
A	MET547
A	THR550
A	ASN551
A	LEU553
A	TYR554
A	ARG557
A	ALA566
A	ILE569
A	ILE573
B	PHE591
B	ILE668
B	LEU669

site_id	AC5
Number of Residues	9
Details	binding site for residue 6O8 B 801

Chain	Residue
B	ASN437
B	VAL440
B	TYR487
B	PHE488
B	ARG491
B	GLU513
B	PHE516
B	TYR554
B	TYR555

site_id	AC6
Number of Residues	3
Details	binding site for residue 6OE B 802

Chain	Residue
B	SER532
B	ARG534
F	6O9101

site_id	AC7
Number of Residues	17
Details	binding site for residue 6EU B 803

Chain	Residue
B	TYR511
B	SER512
B	ILE514
B	LEU515
B	ALA546
B	MET547
B	THR550
B	ASN551
B	LEU553
B	TYR554
B	ARG557
B	ALA566
B	ILE569
B	ILE573
D	PHE591
D	ILE668
D	LEU669

site_id	AC8
Number of Residues	9
Details	binding site for residue 6O8 C 801

Chain	Residue
C	ASN437
C	VAL440
C	TYR487
C	PHE488
C	ARG491
C	GLU513
C	PHE516
C	TYR554
C	TYR555

site_id	AC9
Number of Residues	2
Details	binding site for residue 6OE C 802

Chain	Residue
C	ARG534
E	6O9101

site_id	AD1
Number of Residues	17
Details	binding site for residue 6EU C 803

Chain	Residue
A	PHE591
A	ILE668
A	LEU669
C	TYR511
C	SER512
C	ILE514
C	LEU515
C	ALA546
C	MET547
C	THR550
C	ASN551
C	LEU553
C	TYR554
C	ARG557
C	ALA566
C	ILE569
C	ILE573

site_id	AD2
Number of Residues	9
Details	binding site for residue 6O8 D 801

Chain	Residue
D	TYR555
D	ASN437
D	VAL440
D	TYR487
D	PHE488
D	ARG491
D	GLU513
D	PHE516
D	TYR554

site_id	AD3
Number of Residues	4
Details	binding site for residue 6O9 D 802

Chain	Residue
D	ARG534
D	6OE804
E	VAL50
E	TRP53

site_id	AD4
Number of Residues	5
Details	binding site for residue 6OE D 803

Chain	Residue
B	TYR453
D	SER629
D	TYR631
E	ALA66
E	PHE67

site_id	AD5
Number of Residues	3
Details	binding site for residue 6OE D 804

Chain	Residue
D	SER532
D	ARG534
D	6O9802

site_id	AD6
Number of Residues	17
Details	binding site for residue 6EU D 805

Chain	Residue
C	PHE591
C	ILE668
C	LEU669
D	TYR511
D	SER512
D	ILE514
D	LEU515
D	ALA546
D	MET547
D	THR550
D	ASN551
D	LEU553
D	TYR554
D	ARG557
D	ALA566
D	ILE569
D	ILE573

site_id	AD7
Number of Residues	5
Details	binding site for residue 6O9 E 101

Chain	Residue
C	ARG534
C	6OE802
E	GLU7
E	VAL8
E	TRP11

site_id	AD8
Number of Residues	4
Details	binding site for residue 6OE E 102

Chain	Residue
C	SER629
C	TYR631
D	TYR453
E	GLU26

site_id	AD9
Number of Residues	4
Details	binding site for residue 6O9 F 101

Chain	Residue
B	ARG534
B	6OE802
F	GLU7
F	VAL8

site_id	AE1
Number of Residues	4
Details	binding site for residue 6O9 F 102

Chain	Residue
A	ARG534
A	6OE803
F	GLU49
F	VAL50

site_id	AE2
Number of Residues	4
Details	binding site for residue 6OE F 103

Chain	Residue
A	TYR453
B	SER629
B	TYR631
F	GLU26

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200

Chain	Residue	Details
A	ILE433-TYR453
A	TYR472-LEU497
A	TYR511-PHE531
A	GLU536-THR556
A	MET572-ILE599
A	VAL658-VAL686
B	ILE433-TYR453
B	TYR472-LEU497
B	TYR511-PHE531
B	GLU536-THR556
B	MET572-ILE599
B	VAL658-VAL686
C	ILE433-TYR453
C	TYR472-LEU497
C	TYR511-PHE531
C	GLU536-THR556
C	MET572-ILE599
C	VAL658-VAL686
D	ILE433-TYR453
D	TYR472-LEU497
D	TYR511-PHE531
D	MET572-ILE599
D	VAL658-VAL686
D	GLU536-THR556

site_id	SWS_FT_FI2
Number of Residues	184
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200

Chain	Residue	Details
A	TYR454-ASP471
A	SER532-LYS535
A	GLU600-PHE649
B	TYR454-ASP471
B	SER532-LYS535
B	GLU600-PHE649
C	TYR454-ASP471
C	SER532-LYS535
C	GLU600-PHE649
D	TYR454-ASP471
D	SER532-LYS535
D	GLU600-PHE649

site_id	SWS_FT_FI3
Number of Residues	104
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200

Chain	Residue	Details
A	GLN498-SER510
A	ARG557-LYS571
B	GLN498-SER510
B	ARG557-LYS571
C	GLN498-SER510
C	ARG557-LYS571
D	GLN498-SER510
D	ARG557-LYS571

site_id	SWS_FT_FI4
Number of Residues	88
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0000305\|PubMed:10931826

Chain	Residue	Details
A	TYR627-PHE649
B	TYR627-PHE649
C	TYR627-PHE649
D	TYR627-PHE649

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2PNN

Chain	Residue	Details
B	LYS155
B	GLU210
C	ARG115
C	LYS155
C	GLU210
D	ARG115
D	LYS155
D	GLU210
A	ARG115
A	LYS155
A	GLU210
B	ARG115

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2NYJ, ECO:0007744\|PDB:2PNN

Chain	Residue	Details
B	ASN164
B	TYR199
C	LYS160
C	ASN164
C	TYR199
D	LYS160
D	ASN164
D	TYR199
A	LYS160
A	ASN164
A	TYR199
B	LYS160

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:5IRX

Chain	Residue	Details
B	THR550
B	ARG557
C	TYR511
C	THR550
C	ARG557
D	TYR511
D	THR550
D	ARG557
A	TYR511
A	THR550
A	ARG557
B	TYR511

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9R186

Chain	Residue	Details
A	ASP646
B	ASP646
C	ASP646
D	ASP646

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269\|PubMed:12194871, ECO:0000269\|PubMed:15471852

Chain	Residue	Details
A	SER116
B	SER116
C	SER116
D	SER116

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269\|PubMed:12194871

Chain	Residue	Details
A	THR144
A	THR370
B	THR144
B	THR370
C	THR144
C	THR370
D	THR144
D	THR370

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269\|PubMed:11884385, ECO:0000269\|PubMed:12194871, ECO:0000269\|PubMed:14630912

Chain	Residue	Details
A	SER502
B	SER502
C	SER502
D	SER502

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:14630912

Chain	Residue	Details
A	THR704
B	THR704
C	THR704
D	THR704

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:11683872

Chain	Residue	Details
A	TYR627
B	TYR627
C	TYR627
D	TYR627

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)