Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IRX

Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0008289	molecular_function	lipid binding
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
E	0099106	molecular_function	ion channel regulator activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0008289	molecular_function	lipid binding
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 6O8 A 801

Chain	Residue
A	ASN437
A	VAL440
A	TYR487
A	PHE488
A	ARG491
A	GLU513
A	PHE516
A	TYR554
A	TYR555

site_id	AC2
Number of Residues	5
Details	binding site for residue 6OE A 802

Chain	Residue
A	SER629
A	TYR631
C	TYR453
F	ALA66
F	PHE67

site_id	AC3
Number of Residues	3
Details	binding site for residue 6OE A 803

Chain	Residue
A	SER532
A	ARG534
F	6O9102

site_id	AC4
Number of Residues	17
Details	binding site for residue 6EU A 804

Chain	Residue
A	TYR511
A	SER512
A	ILE514
A	LEU515
A	ALA546
A	MET547
A	THR550
A	ASN551
A	LEU553
A	TYR554
A	ARG557
A	ALA566
A	ILE569
A	ILE573
B	PHE591
B	ILE668
B	LEU669

site_id	AC5
Number of Residues	9
Details	binding site for residue 6O8 B 801

Chain	Residue
B	ASN437
B	VAL440
B	TYR487
B	PHE488
B	ARG491
B	GLU513
B	PHE516
B	TYR554
B	TYR555

site_id	AC6
Number of Residues	3
Details	binding site for residue 6OE B 802

Chain	Residue
B	SER532
B	ARG534
F	6O9101

site_id	AC7
Number of Residues	17
Details	binding site for residue 6EU B 803

Chain	Residue
B	TYR511
B	SER512
B	ILE514
B	LEU515
B	ALA546
B	MET547
B	THR550
B	ASN551
B	LEU553
B	TYR554
B	ARG557
B	ALA566
B	ILE569
B	ILE573
D	PHE591
D	ILE668
D	LEU669

site_id	AC8
Number of Residues	9
Details	binding site for residue 6O8 C 801

Chain	Residue
C	ASN437
C	VAL440
C	TYR487
C	PHE488
C	ARG491
C	GLU513
C	PHE516
C	TYR554
C	TYR555

site_id	AC9
Number of Residues	2
Details	binding site for residue 6OE C 802

Chain	Residue
C	ARG534
E	6O9101

site_id	AD1
Number of Residues	17
Details	binding site for residue 6EU C 803

Chain	Residue
A	PHE591
A	ILE668
A	LEU669
C	TYR511
C	SER512
C	ILE514
C	LEU515
C	ALA546
C	MET547
C	THR550
C	ASN551
C	LEU553
C	TYR554
C	ARG557
C	ALA566
C	ILE569
C	ILE573

site_id	AD2
Number of Residues	9
Details	binding site for residue 6O8 D 801

Chain	Residue
D	TYR555
D	ASN437
D	VAL440
D	TYR487
D	PHE488
D	ARG491
D	GLU513
D	PHE516
D	TYR554

site_id	AD3
Number of Residues	4
Details	binding site for residue 6O9 D 802

Chain	Residue
D	ARG534
D	6OE804
E	VAL50
E	TRP53

site_id	AD4
Number of Residues	5
Details	binding site for residue 6OE D 803

Chain	Residue
B	TYR453
D	SER629
D	TYR631
E	ALA66
E	PHE67

site_id	AD5
Number of Residues	3
Details	binding site for residue 6OE D 804

Chain	Residue
D	SER532
D	ARG534
D	6O9802

site_id	AD6
Number of Residues	17
Details	binding site for residue 6EU D 805

Chain	Residue
C	PHE591
C	ILE668
C	LEU669
D	TYR511
D	SER512
D	ILE514
D	LEU515
D	ALA546
D	MET547
D	THR550
D	ASN551
D	LEU553
D	TYR554
D	ARG557
D	ALA566
D	ILE569
D	ILE573

site_id	AD7
Number of Residues	5
Details	binding site for residue 6O9 E 101

Chain	Residue
C	ARG534
C	6OE802
E	GLU7
E	VAL8
E	TRP11

site_id	AD8
Number of Residues	4
Details	binding site for residue 6OE E 102

Chain	Residue
C	SER629
C	TYR631
D	TYR453
E	GLU26

site_id	AD9
Number of Residues	4
Details	binding site for residue 6O9 F 101

Chain	Residue
B	ARG534
B	6OE802
F	GLU7
F	VAL8

site_id	AE1
Number of Residues	4
Details	binding site for residue 6O9 F 102

Chain	Residue
A	ARG534
A	6OE803
F	GLU49
F	VAL50

site_id	AE2
Number of Residues	4
Details	binding site for residue 6OE F 103

Chain	Residue
A	TYR453
B	SER629
B	TYR631
F	GLU26

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	104
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	88
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	92
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	112
Details	Region: {"description":"AD","evidences":[{"source":"PubMed","id":"15190102","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"10931826","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by PKA; in vitro","evidences":[{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"11884385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	58
Details	Repeat: {"description":"Domain 1","evidences":[{"source":"PubMed","id":"20510930","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	58
Details	Repeat: {"description":"Domain 2","evidences":[{"source":"PubMed","id":"20510930","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	138
Details	Region: {"description":"2 X approximate repeats with cysteine pattern C-C-CC-C-C","evidences":[{"source":"PubMed","id":"20510930","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	8
Details	Site: {"description":"Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix)","evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	2
Details	Site: {"description":"Important residue for activation of TRPV1","evidences":[{"source":"PubMed","id":"26880553","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Site: {"description":"Important residue for activation of TRPV1","evidences":[{"source":"PubMed","id":"26880553","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)